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Alsin is partially associated with centrosome in human cells
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title
Alsin is partially associated with centrosome in human cells
(English)
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main subject
Alsin Rho guanine nucleotide exchange factor ALS2
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stated in
GOA release 2020-03-11
Alsin Rho guanine nucleotide exchange factor
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stated in
GOA release 2020-03-11
author
Guy A. Rouleau
series ordinal
4
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François Gros-Louis
series ordinal
3
object named as
François Gros-Louis
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Jean-Pierre Julien
series ordinal
5
object named as
Jean-Pierre Julien
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Stéphanie Millecamps
series ordinal
1
object named as
Stéphanie Millecamps
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author name string
Benoît J Gentil
series ordinal
2
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language of work or name
English
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publication date
15 August 2005
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published in
Biochimica et Biophysica Acta
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volume
1745
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issue
1
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page(s)
84-100
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cites work
AnALS2gene mutation causes hereditary spastic paraplegia in a Pakistani kindred
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Sequence variants in human neurofilament proteins: absence of linkage to familial amyotrophic lateral sclerosis
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Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis
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Enzymatic activities during differentiation of the human neuroblastoma cells, LA-N-1 and LA-N-2.
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SV40-transformed simian cells support the replication of early SV40 mutants
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7 January 2021
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Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome
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reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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7 January 2021
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γ-Tubulin is a highly conserved component of the centrosome
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reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
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reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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In vitro reconstitution of centrosome assembly and function: the central role of gamma-tubulin
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reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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Pericentrin, a highly conserved centrosome protein involved in microtubule organization
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Cu/Zn superoxide dismutase (SOD1) mutations and sporadic amyotrophic lateral sclerosis
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Use of Rab-GDP dissociation inhibitor for solubilization and delivery of Rab proteins to biological membranes in streptolysin O-permeabilized cells
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https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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Microtubules and neuronal polarity: lessons from mitosis
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The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings
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Crossref
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Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality
1 reference
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Rab5 regulates motility of early endosomes on microtubules
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https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1
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Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product
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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
retrieved
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inferred from DOI database lookup
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis
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reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
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Crossref
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Rocks: multifunctional kinases in cell behaviour
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Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease
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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
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Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts
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The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting
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Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking
1 reference
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A frameshift deletion in peripherin gene associated with amyotrophic lateral sclerosis
1 reference
stated in
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https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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inferred from DOI database lookup
A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion
1 reference
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Crossref
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Regulated expression of vimentin cDNA in cells in the presence and absence of a preexisting vimentin filament network
1 reference
stated in
Crossref
reference URL
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Microtubule nucleation and release from the neuronal centrosome
1 reference
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Crossref
reference URL
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Transport of dendritic microtubules establishes their nonuniform polarity orientation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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inferred from DOI database lookup
Gamma-tubulin can both nucleate microtubule assembly and self-assemble into novel tubular structures in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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Microtubule transport and assembly during axon growth
1 reference
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Crossref
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Analysis of Tub4p, a yeast gamma-tubulin-like protein: implications for microtubule-organizing center function
1 reference
stated in
Crossref
reference URL
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When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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7 January 2021
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inferred from DOI database lookup
Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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7 January 2021
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inferred from DOI database lookup
Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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inferred from DOI database lookup
Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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7 January 2021
based on heuristic
inferred from DOI database lookup
Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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7 January 2021
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inferred from DOI database lookup
DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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7 January 2021
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ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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7 January 2021
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inferred from DOI database lookup
Novel insertion in the KSP region of the neurofilament heavy gene in amyotrophic lateral sclerosis (ALS)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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A novel somatodendritic marker defined by a peptide derived from the ALS2 protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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7 January 2021
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inferred from DOI database lookup
Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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7 January 2021
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inferred from DOI database lookup
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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7 January 2021
based on heuristic
inferred from DOI database lookup
A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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7 January 2021
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inferred from DOI database lookup
Increased activation of Ras in psoriatic lesions
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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7 January 2021
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inferred from DOI database lookup
Infantile ascending hereditary spastic paralysis (IAHSP): clinical features in 11 families
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
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7 January 2021
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inferred from DOI database lookup
Analysis of the KSP repeat of the neurofilament heavy subunit in familiar amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2004.12.008
retrieved
7 January 2021
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inferred from DOI database lookup
Identifiers
DOI
10.1016/J.BBAMCR.2004.12.008
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Fatcat ID
release_ou5rarygobedvgr4p3yjs7owoq
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PubMed publication ID
16085057
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ResearchGate publication ID
7675211
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