(Q24322745)

GOA release 2020-03-11

Sirtuin 2

1 reference

proteasome-mediated ubiquitin-dependent protein catabolic process

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

protein ubiquitination

1 reference

F Wang

1

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C-H Chan

2

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K Chen

3

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X Guan

4

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H-K Lin

5

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Q Tong

FOXO animal models reveal a variety of diverse roles for FOXO transcription factors

6

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language of work or name

English

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publication date

22 March 2012

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published in

Oncogene

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volume

31

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issue

12

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page(s)

1546-57

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Regulation of Skp2 expression and activity and its role in cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Unravelling the tumor-suppressive functions of FOXO proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

SIRT1, is it a tumor promoter or tumor suppressor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Structure of the histone deacetylase SIRT2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

FOXOs, cancer and regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

The role of FoxO in the regulation of metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Many forks in the path: cycling with FoxO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

SirT1 is an inhibitor of proliferation and tumor formation in colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Increased life span due to calorie restriction in respiratory-deficient yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Sir2-independent life span extension by calorie restriction in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

HST2 mediates SIR2-independent life-span extension by calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

The critical role of the class III histone deacetylase SIRT1 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Mammalian SIRT1 represses forkhead transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Structure/function relationships underlying regulation of FOXO transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Mechanisms underlying ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Conserved metabolic regulatory functions of sirtuins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

FoxO transcription factors in oxidative stress response and ageing--a new fork on the way to longevity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

E3 ubiquitin ligases as cancer targets and biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Balance between SIRT1 and DBC1 expression is lost in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

AROuSing SIRT1: identification of a novel endogenous SIRT1 activator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

The E3 ligase TRAF6 regulates Akt ubiquitination and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347

Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.347