(Q24337155)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192271%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

title

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192271%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

0 references

0 references

Histone deacetylase 6

1 reference

cellular response to topologically incorrect protein

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Atsushi Iwata

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192271%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Jennifer A. Johnston

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192271%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

author name string

Brigit E Riley

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192271%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Ron R Kopito

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192271%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

language of work or name

English

0 references

publication date

28 September 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192271%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

number of pages

11

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192271%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

volume

280

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192271%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

page(s)

40282-40292

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192271%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

issue

48

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192271%20AND%20SRC:MED&resulttype=core&format=json

Glutamine repeats and neurodegeneration

7 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Mouse models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Toxic proteins in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Deadly conformations--protein misfolding in prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

21 January 2018

Conformational disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Protein aggregation and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

A Unified Nomenclature for Yeast Autophagy-Related Genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Vacuolar import of proteins and organelles from the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Autophagy regulates the processing of amino terminal huntingtin fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Upstream and downstream of mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Huntingtin localization in brains of normal and Huntington's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Aggresomes: a cellular response to misfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Aggresomes, inclusion bodies and protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Autophagy: a regulated bulk degradation process inside cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Translocation and clustering of endosomes and lysosomes depends on microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

The mitochondrial permeability transition initiates autophagy in rat hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Vacuolar localization of oligomeric alpha-mannosidase requires the cytoplasm to vacuole targeting and autophagy pathway components in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

HDAC6 is a microtubule-associated deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

The missing linker: an unexpected role for a histone deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Involvement of macroautophagy in the dissolution of neuronal inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

7 January 2021

inferred from DOI database lookup

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

7 January 2021

inferred from DOI database lookup

Emerging role for autophagy in the removal of aggresomes in Schwann cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508786200

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1074/JBC.M508786200

2 references

Consolidated OpenCitations Corpus – April 2017

2828539

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192271%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

2828539

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

2828539