(Q24548250)

English

8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways

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2 December 2019

8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways (English)

1 reference

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2 December 2019

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Géraldine Guasch

1

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2 December 2019

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2 December 2019

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V Ollendorff

2

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2 December 2019

D Birnbaum

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2 December 2019

M J Pébusque

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1 December 2001

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2 December 2019

Molecular and Cellular Biology

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2 December 2019

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2 December 2019

8129-8142

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2 December 2019

23

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Europe PubMed Central

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2 December 2019

Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development

1 reference

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24 March 2017

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

1 reference

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24 March 2017

FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

1 reference

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24 March 2017

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

1 reference

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24 March 2017

Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)

1 reference

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24 March 2017

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

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24 March 2017

Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras

1 reference

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24 March 2017

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

1 reference

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24 March 2017

Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction

1 reference

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24 March 2017

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase

1 reference

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24 March 2017

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors

1 reference

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24 March 2017

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

27 September 2017

TOR, a central controller of cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

Oncogenic kinase signalling

1 reference

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24 March 2017

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

1 reference

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24 March 2017

Met receptor tyrosine kinase: enhanced signaling through adapter proteins

1 reference

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24 March 2017

Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

1 reference

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24 March 2017

Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

Fibroblast growth factor receptors: lessons from the genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

FGFR activation in skeletal disorders: too much of a good thing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

Fibroblast growth factor receptors have different signaling and mitogenic potentials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

24 March 2017

Cellular survival: a play in three Akts

1 reference

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7 April 2017

Regulation of translation initiation by FRAP/mTOR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

7 April 2017

STATs in oncogenesis

1 reference

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7 April 2017

Stat3 as an oncogene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

7 April 2017

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

7 April 2017

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

1 reference

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7 April 2017

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

7 April 2017

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1 reference

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7 April 2017

Growth factor signaling by receptor tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

7 April 2017

A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt.

1 reference

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27 September 2017

Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl

1 reference

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27 September 2017

Src homology 2-containing inositol 5-phosphatase 1 binds to the multifunctional docking site of c-Met and potentiates hepatocyte growth factor-induced branching tubulogenesis.

1 reference

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27 September 2017

The role of Stat5a and Stat5b in signaling by IL-2 family cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

27 September 2017

Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

27 September 2017

Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

27 September 2017

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

27 September 2017

Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

27 September 2017

The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

27 September 2017

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

27 September 2017

Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

27 September 2017

Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes.

1 reference

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27 September 2017

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

1 reference

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27 September 2017

Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor

1 reference

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27 September 2017

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

1 reference

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27 September 2017

Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines.

1 reference

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27 September 2017

PI 3-kinase: structural and functional analysis of intersubunit interactions

1 reference

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27 September 2017

How receptor tyrosine kinases activate Ras.

1 reference

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27 September 2017

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1 reference

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27 September 2017

Ligand-induced transphosphorylation between different FGF receptors

1 reference

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27 September 2017

K-sam-related gene, N-sam, encodes fibroblast growth factor receptor and is expressed in T-lymphocytic tumors

1 reference

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27 September 2017

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

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30 May 2018

Signalling via phosphoinositide 3OH kinases.

1 reference

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30 May 2018

TOR signalling and control of cell growth

1 reference

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30 May 2018

The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells--signals emanating from the erythropoietin receptor

1 reference

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30 May 2018

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99978

30 May 2018

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.

1 reference

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28 November 2018

Structure and function of phosphoinositide 3-kinases.

1 reference

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28 November 2018

A mitogen-activated protein kinase pathway is required for mu-opioid receptor desensitization

1 reference

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28 November 2018

Signal transduction by fibroblast growth factor receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11689702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11689702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11689702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11689702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11689702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11689702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

t(6;8), t(8;9) and t(8;13) translocations associated with stem cell myeloproliferative disorders have close or identical breakpoints in chromosome region 8p11-12

1 reference

https://pubmed.ncbi.nlm.nih.gov/11689702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 expression by myeloid precursors in myelodysplastic syndromes: relation to disease progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11689702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11689702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1)

1 reference

https://api.crossref.org/works/10.1128%2FMCB.21.23.8129-8142.2001

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1128/MCB.21.23.8129-8142.2001

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11689702%20AND%20SRC:MED&resulttype=core&format=json

2 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11689702%20AND%20SRC:MED&resulttype=core&format=json

2 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11689702%20AND%20SRC:MED&resulttype=core&format=json

2 December 2019

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