(Q24631332)

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The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance

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The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance (English)

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Mycobacterium tuberculosis

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drug resistance

1 reference

based on heuristic

inferred from title

author name string

Richa Rawat

1

author given names

Richa

author last names

Rawat

1 reference

PubMed publication ID

19 October 2023

Adrian Whitty

2

author given names

Adrian

author last names

Whitty

1 reference

PubMed publication ID

19 October 2023

Peter J Tonge

3

author given names

Peter J

author last names

Tonge

1 reference

PubMed publication ID

19 October 2023

language of work or name

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publication date

25 November 2003

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Proceedings of the National Academy of Sciences of the United States of America

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100

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24

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13881-6

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Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

7 April 2017

Modification of the NADH of the Isoniazid Target (InhA) from Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

7 April 2017

Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

7 April 2017

MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

7 April 2017

Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

7 April 2017

InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

7 April 2017

Triclosan targets lipid synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

7 April 2017

Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

7 April 2017

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

7 April 2017

Tuberculosis: commentary on a reemergent killer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

7 April 2017

The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

7 April 2017

Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

27 September 2017

Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

27 September 2017

Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

27 September 2017

Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

27 September 2017

Multidrug-Resistant Mycobacterium tuberculosis: Molecular Perspectives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

27 September 2017

Antimicrobial agent resistance in mycobacteria: molecular genetic insights.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

27 September 2017

Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

27 September 2017

The behavior and significance of slow-binding enzyme inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

27 September 2017

Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

30 May 2018

Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283515

30 May 2018

Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235848100

21 January 2018

Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235848100

21 January 2018

Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235848100

21 January 2018

Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235848100

21 January 2018

Alpha 1-proteinase inhibitor variant T345R. Influence of P14 residue on substrate and inhibitory pathways

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235848100

21 January 2018

Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235848100

21 January 2018

Roles of Tyrosine 158 and Lysine 165 in the Catalytic Mechanism of InhA, the Enoyl-ACP Reductase fromMycobacterium tuberculosis†

1 reference

https://pubmed.ncbi.nlm.nih.gov/14623976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalase-peroxidase gene sequences in isoniazid-sensitive and -resistant strains of Mycobacterium tuberculosis from New York City

1 reference

https://pubmed.ncbi.nlm.nih.gov/14623976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory mechanism of serpins. Interaction of thrombin with antithrombin and protease nexin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/14623976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Susceptibility to levofloxacin of Myocobacterium tuberculosis isolates from patients with HIV-related tuberculosis and characterization of a strain with levofloxacin monoresistance. Community Programs for Clinical Research on AIDS 019 and the AIDS C

1 reference

https://pubmed.ncbi.nlm.nih.gov/14623976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-performance ion-exchange separation of oxidized and reduced nicotinamide adenine dinucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/14623976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of phosphatidylcholine liposomes on the fatty acid synthetase complex from Mycobacterium smegmatis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14623976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Action mechanism of antitubercular isoniazid. Activation by Mycobacterium tuberculosis KatG, isolation, and characterization of inha inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/14623976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous Formation of the Bioactive Form of the Tuberculosis Drug Isoniazid

1 reference

https://pubmed.ncbi.nlm.nih.gov/14623976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In-vitro activity of grepafloxacin, a new fluoroquinolone, against mycoplasmas

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235848100

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1073/PNAS.2235848100

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2003PNAS..10013881R

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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