(Q24645466)

English

Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy

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scholarly article

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Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy (English)

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1 reference

based on heuristic

inferred from title

6

object named as

Sagar Lonial

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7

object named as

Fadlo R Khuri

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author name string

Lei Fu

1

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Young-Ae Kim

2

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Xuerong Wang

3

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Xiaoyun Wu

4

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Ping Yue

5

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Shi-Yong Sun

8

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language of work or name

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publication date

1 December 2009

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Cancer Research

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69

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23

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8967-76

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

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7 April 2017

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789206

7 April 2017

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789206

7 April 2017

Autophagy fights disease through cellular self-digestion

1 reference

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7 April 2017

Autophagy in the Pathogenesis of Disease

1 reference

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7 April 2017

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

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7 April 2017

An expanding role for mTOR in cancer

1 reference

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7 April 2017

Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789206

7 April 2017

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

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How to interpret LC3 immunoblotting

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mTOR and cancer: insights into a complex relationship

1 reference

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

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Exploiting the PI3K/AKT pathway for cancer drug discovery

1 reference

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7 April 2017

Autophagy in cell death: an innocent convict?

1 reference

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7 April 2017

The TOR pathway: a target for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789206

7 April 2017

Potential therapeutic applications of autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789206

7 April 2017

Perifosine: update on a novel Akt inhibitor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789206

27 September 2017

FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression

1 reference

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27 September 2017

Pharmacodynamic markers of perifosine efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789206

27 September 2017

Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components

1 reference

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Dynamic FoxO transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789206

27 September 2017

The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789206

27 September 2017

Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in PTEN-deficient cancer cells

1 reference

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The Akt-mTOR tango and its relevance to cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2789206

27 September 2017

Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo

1 reference

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Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid

1 reference

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Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species

1 reference

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Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells.

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In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines

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Inactivation of hCDC4 can cause chromosomal instability

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Will mTOR inhibitors make it as cancer drugs?

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Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways

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Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19920197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-09-2190

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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