(Q24647515)

2

0 references

Wei Li

3

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Stephan A Luis

4

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Trevor P Baglin

5

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James A Huntington

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

17 November 2006

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published in

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volume

281

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issue

46

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page(s)

35478-86

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cites work

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The anticoagulant activation of antithrombin by heparin

7 April 2017

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The Influence of Hinge Region Residue Glu-381 on Antithrombin Allostery and Metastability

7 April 2017

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Crystal structure of antithrombin in a heparin-bound intermediate state

7 April 2017

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The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form

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Structure of beta-antithrombin and the effect of glycosylation on antithrombin's heparin affinity and activity

7 April 2017

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Serpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerol

7 April 2017

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7 April 2017

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Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.

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The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity

27 September 2017

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Heparin activates antithrombin anticoagulant function by generating new interaction sites (exosites) for blood clotting proteinases.

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The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation

27 September 2017

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Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin.

27 September 2017

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Conformational conversion of antithrombin to a fully activated substrate of factor Xa without need for heparin

27 September 2017

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Heparin-dependent modification of the reactive center arginine of antithrombin and consequent increase in heparin binding affinity

27 September 2017

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Mechanism of heparin activation of antithrombin. Evidence for reactive center loop preinsertion with expulsion upon heparin binding

27 September 2017

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Antithrombin-heparin affinity reduced by fucosylation of carbohydrate at asparagine 155.

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Antithrombin Glasgow, 393 arg to his: A P1reactive site variant with increased heparin affinity but no thrombin inhibitory activity

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