(Q27640477)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12578831%20AND%20SRC:MED&resulttype=core&format=json

18 December 2019

title

Serpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerol (English)

1 reference

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18 December 2019

1

1 reference

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18 December 2019

author name string

Penelope E Stein

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12578831%20AND%20SRC:MED&resulttype=core&format=json

18 December 2019

James A Huntington

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12578831%20AND%20SRC:MED&resulttype=core&format=json

18 December 2019

Robin W Carrell

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12578831%20AND%20SRC:MED&resulttype=core&format=json

18 December 2019

language of work or name

English

0 references

publication date

10 February 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12578831%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

18 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12578831%20AND%20SRC:MED&resulttype=core&format=json

18 December 2019

volume

278

1 reference

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18 December 2019

issue

17

1 reference

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18 December 2019

page(s)

15116-15122

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12578831%20AND%20SRC:MED&resulttype=core&format=json

What do dysfunctional serpins tell us about molecular mobility and disease?

18 December 2019

cites work

1 reference

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Alpha1-antitrypsin deficiency--a model for conformational diseases

21 January 2018

1 reference

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Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

21 January 2018

1 reference

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Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

21 January 2018

1 reference

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Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

1 reference

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Conformational changes in serpins: I. The native and cleaved conformations of alpha(1)-antitrypsin

21 January 2018

1 reference

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A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease.

21 January 2018

1 reference

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COOH-terminal substitutions in the serpin C1 inhibitor that cause loop overinsertion and subsequent multimerization

21 January 2018

1 reference

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Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

21 January 2018

1 reference

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Association between conformational mutations in neuroserpin and onset and severity of dementia

21 January 2018

1 reference

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Serpinopathies and the conformational dementias

21 January 2018

1 reference

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The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions

21 January 2018

1 reference

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Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

21 January 2018

1 reference

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Structural basis of latency in plasminogen activator inhibitor-1

21 January 2018

1 reference

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Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

The Size and Shape of Human and Bovine Antithrombin III

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

Isolation and properties of human plasma α-1-proteinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

The anticoagulant activation of antithrombin by heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin

21 January 2018

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

Raster3D: photorealistic molecular graphics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

Probing serpin reactive-loop conformations by proteolytic cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

Interactions causing the kinetic trap in serpin protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

Importance of the amino-acid composition of the shutter region of plasminogen activator inhibitor-1 for its transitions to latent and substrate forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

Structural transition of alpha 1-antitrypsin by a peptide sequentially similar to beta-strand s4A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

A simple two-step procedure for the isolation of antithrombin III from biological fluids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

Further additions to MolScript version 1.4, including reading and contouring of electron-density maps

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211663200

21 January 2018

Identifiers

DOI

10.1074/JBC.M211663200

2 references

Consolidated OpenCitations Corpus – April 2017

1353396

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12578831%20AND%20SRC:MED&resulttype=core&format=json

18 December 2019

1353396

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

1353396