(Q24648725)

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The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine

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scholarly article

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The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine (English)

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Evan D Kharasch

5

object named as

Evan D Kharasch

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author name string

Michael C Montana

1

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Laura F Cavallone

2

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Kristi K Stubbert

3

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Andrei D Stefanescu

4

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Robert W Gereau

6

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language of work or name

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publication date

September 2009

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Journal of Pharmacology and Experimental Therapeutics

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330

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3

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834-43

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A pilot open label, single dose trial of fenobam in adults with fragile X syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

7 April 2017

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

7 April 2017

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

1 reference

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7 April 2017

Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception

2 references

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7 April 2017

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28 September 2017

Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP

1 reference

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7 April 2017

Treatment of anxiety using fenobam (a nonbenzodiazepine) in a double-blind standard (diazepam) placebo-controlled study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

7 April 2017

Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

7 April 2017

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

7 April 2017

Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

28 September 2017

The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

28 September 2017

The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

28 September 2017

Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

28 September 2017

Physiological roles and therapeutic potential of metabotropic glutamate receptors

1 reference

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28 September 2017

Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

28 September 2017

mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

28 September 2017

The use of NMDA-receptor antagonists in the treatment of chronic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

28 September 2017

Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

28 November 2018

Role of central and peripheral mGluR5 receptors in post-operative pain in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

28 November 2018

The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

28 November 2018

Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2729799

28 November 2018

Genetic influences in opioid analgesic sensitivity in mice

1 reference

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28 November 2018

Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in rodents: detailed investigations with a selective

1 reference

https://pubmed.ncbi.nlm.nih.gov/19515968

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19515968

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral group I metabotropic glutamate receptors modulate nociception in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19515968

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What is the quality of the implemented meta-analytic procedures in chronic pain treatment meta-analyses?

1 reference

https://api.crossref.org/works/10.1124%2FJPET.109.154138

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1124/JPET.109.154138

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