(Q34564332)

3 August 2017

1 reference

title

Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. (English)

1 reference

3 August 2017

Paul M Lea

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6494124&resulttype=core&format=json

14 May 2020

Alan I Faden

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6494124&resulttype=core&format=json

14 May 2020

publication date

1 January 2006

1 reference

CNS Neuroscience & Therapeutics

3 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6494124&resulttype=core&format=json

14 May 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6494124&resulttype=core&format=json

14 May 2020

page(s)

149-166

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6494124&resulttype=core&format=json

14 May 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6494124&resulttype=core&format=json

Effect of pentylenetetrazol-induced epileptic seizure on the antioxidant enzyme activities, glutathione and lipid peroxidation levels in rat erythrocytes and liver tissues

14 May 2020

cites work

1 reference

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Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems.

21 January 2018

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Kindled seizures increase metabotropic glutamate receptor expression and function in the rat supraoptic nucleus.

21 January 2018

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Beta-amyloid-induced apoptosis of cerebellar granule cells and cortical neurons: exacerbation by selective inhibition of group I metabotropic glutamate receptors.

21 January 2018

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In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine).

21 January 2018

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[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization

21 January 2018

1 reference

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Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease

21 January 2018

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The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain

21 January 2018

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mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior

21 January 2018

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The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison

21 January 2018

1 reference

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Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia

21 January 2018

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Comparison of the effect of glutamate receptor modulators in the 6 Hz and maximal electroshock seizure models

21 January 2018

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Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis

21 January 2018

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Selective blockade of type-1 metabotropic glutamate receptors induces neuroprotection by enhancing gabaergic transmission

21 January 2018

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Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

21 January 2018

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Interaction with the NMDA receptor locks CaMKII in an active conformation

21 January 2018

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Interaction between metabotropic and NMDA glutamate receptors in the periaqueductal grey pain modulatory system

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Distribution and developmental changes in metabotropic glutamate receptor messenger RNA expression in the rat lumbar spinal cord

21 January 2018

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mGlu5 receptor antagonist decreases Fos expression in spinal neurons after noxious visceral stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Actions of the systemically active metabotropic glutamate antagonist MPEP on sensory responses of thalamic neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Involvement of mGluR(5) on acute nociceptive transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Metabotropic glutamate receptor 5 antagonist-induced stimulation of hypothalamic-pituitary-adrenal axis activity: interaction with serotonergic systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Homer: a protein that selectively binds metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Reduced stress-induced hyperthermia in mGluR5 knockout mice

21 January 2018

1 reference

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Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs

21 January 2018

1 reference

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Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

AMPA neurotoxicity in cultured cerebellar granule neurons: mode of cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Dissecting G protein-coupled receptor signaling pathways with membrane-permeable blocking peptides. Endogenous 5-HT(2C) receptors in choroid plexus epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Zinc neurotoxicity in cortical cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Simultaneous blockade of adenosine A2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Pharmacology and functions of metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

[3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Energy metabolism and protein phosphorylation during apoptosis: a phosphorylation study of tau and high-molecular-weight tau in differentiated PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Modulatory effects mediated by metabotropic glutamate receptor 5 on lateral geniculate nucleus relay cells

21 January 2018

1 reference

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Up-regulation of metabotropic glutamate receptor subtypes 3 and 5 in spinal cord in a clinical model of persistent inflammation and hyperalgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Chronic treatment with the mGlu5R antagonist MPEP reduces the functional effects of the mGlu5R agonist CHPG in the striatum of 6-hydroxydopamine-lesioned rats: possible relevance to the effects of mGlu5R blockade in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improvesoOutcome after brain trauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Opposing effects of protein kinase C and protein kinase A on metabotropic glutamate receptor signaling: selective desensitization of the inositol trisphosphate/Ca2+ pathway by phosphorylation of the receptor-G protein-coupling domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Differential localization of the mRNAs for the pertussis toxin insensitive G-protein alpha sub-units Gq, G11, and Gz in the rat brain, and regulation of their expression after striatal deafferentation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Discovery and characterization of non-competitive antagonists of group I metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Neuroadaptations in ionotropic and metabotropic glutamate receptor mRNA produced by cocaine treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Developmentally regulated gene expression of all eight metabotropic glutamate receptors in hypothalamic suprachiasmatic and arcuate nuclei--a PCR analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The role of striatal metabotropic glutamate receptors in degeneration of dopamine neurons: review article

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Neuroprotective action of MPEP, a selective mGluR5 antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibition of hyperthermia in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

In vitro metabolic studies on the selective metabotropic glutamate receptor sub-type 5 (mGluR5) antagonist 3-[(2-methyl-1,3-thiazol-4-yl) ethynyl]-pyridine (MTEP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Acute activation of the spinal cord metabotropic glutamate subtype-5 receptor leads to cold hypersensitivity in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Antihyperalgesic effect of the cannabinoid agonist WIN55,212-2 is mediated through an interaction with spinal metabotropic glutamate-5 receptors in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Nicotine potentiation of brain stimulation reward reversed by DH beta E and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Signal discrimination in the semicircular canals: a role for group I metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Addiction: a disease of learning and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Separation-induced ultrasonic vocalization in rat pups: further pharmacological characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Diversity of calcium signaling by metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Modulation of stretch-induced enhancement of neuronal NMDA receptor current by mGluR1 depends upon presence of glia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Neuronal and glial mGluR5 modulation prevents stretch-induced enhancement of NMDA receptor current

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Differential roles of mGluR1 and mGluR5 in brief and prolonged nociceptive processing in central amygdala neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Anticonvulsant action of an antagonist of metabotropic glutamate receptors mGluR5 MPEP in immature rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Group I metabotropic glutamate antagonist reduces acute neuronal degeneration and behavioral deficits after traumatic brain injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

MPEP, an antagonist of metabotropic glutamate receptors, exhibits anticonvulsant action in immature rats without a serious impairment of motor performance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Activation of mGlu1 but not mGlu5 metabotropic glutamate receptors contributes to postischemic neuronal injury in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Group I metabotropic glutamate receptors in spinal cord injury: roles in neuroprotection and the development of chronic central pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Glutamate metabotropic receptors as targets for drug therapy in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Repeated administration of group I mGluR antagonists prevents seizure-induced long-term aberrations in hippocampal synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Involvement of spinal metabotropic glutamate receptor 5 in the development of tolerance to morphine-induced antinociception

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Historical review: Molecular and cellular mechanisms of opiate and cocaine addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Excitotoxins in neuronal apoptosis and necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The up-regulation of metabotropic glutamate receptor 5 (mGluR5) in Down's syndrome brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Tyrosine phosphorylation of the metabotropic glutamate receptor mGluR5 in striatal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The role of striatal metabotropic glutamate receptors in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Dysfunction of the cortico-basal ganglia-cortical loop in a rat model of early parkinsonism is reversed by metabotropic glutamate receptor 5 antagonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Blockade of the mGlu5 receptor decreases basal and stress-induced cortical norepinephrine in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Interaction between vanilloid and glutamate receptors in the central modulation of nociception

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Developmental and sensory-dependent changes of phosphoinositide-linked metabotropic glutamate receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Pharmacological characterization of stress-induced hyperthermia in DBA/2 mice using metabotropic and ionotropic glutamate receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Kainate induces apoptosis in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Kainic acid induces apoptosis in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The role of metabotropic glutamate receptor 5 in learning and memory processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Age differences in the expression of metabotropic glutamate receptor 1 and inositol 1,4,5-trisphosphate receptor in mouse cerebellum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Changes in mRNA levels for group I metabotropic glutamate receptors following in utero hypoxia-ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Recent advances in non-competitive mGlu5 receptor antagonists and their potential therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Internalization of ionotropic glutamate receptors in response to mGluR activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Effects of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression test.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Determination of group I metabotropic glutamate receptor subtypes involved in the frequency of epileptiform activity in vitro using mGluR1 and mGluR5 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The regulation of reactive oxygen species production during programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Group I mGluRs modulate the pattern of non-synaptic epileptiform activity in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Functional interaction between mGlu 5 and NMDA receptors in a rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Neuroprotective effects of metabotropic glutamate receptor ligands in a 6-hydroxydopamine rodent model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Metabotropic glutamate receptors and the generation of locomotor activity: interactions with midbrain dopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The role of metabotropic glutamate receptors in regulation of striatal proenkephalin expression: implications for the therapy of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Alterations in calcium-mediated signal transduction after traumatic injury of cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Overwhelmingly asynchronous firing of rat subthalamic nucleus neurones in brain slices provides little evidence for intrinsic interconnectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

In vitro microsomal metabolic studies on a selective mGluR5 antagonist MTEP: characterization of in vitro metabolites and identification of a novel thiazole ring opening aldehyde metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Mediation of neuronal apoptosis by enhancement of outward potassium current.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Reduction of voltage-dependent Mg2+ blockade of NMDA current in mechanically injured neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Dual modulation of excitatory synaptic transmission by agonists at group I metabotropic glutamate receptors in the rat spinal dorsal horn.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Role of central and peripheral mGluR5 receptors in post-operative pain in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2006.00149.X

The glutamate receptor ion channels

21 January 2018

1 reference

12 December 2020

Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 r

1 reference

12 December 2020

Reactive oxygen species as mediators of photoreceptor apoptosis in vitro

1 reference

12 December 2020

Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells.

1 reference

12 December 2020

Subtype-dependence of NMDA receptor channel open probability.

1 reference

12 December 2020

Enhancement of AMPA-mediated current after traumatic injury in cortical neurons.

1 reference

12 December 2020

Glutamate triggers preferential Zn2+ flux through Ca2+ permeable AMPA channels and consequent ROS production.

1 reference

12 December 2020

Metabotropic glutamate receptor protein alterations after traumatic brain injury in rats

1 reference

12 December 2020

Metabotropic glutamate receptor mRNA expression in the schizophrenic thalamus

1 reference

12 December 2020

Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients

1 reference

12 December 2020

Stretch injury causes calpain and caspase-3 activation and necrotic and apoptotic cell death in septo-hippocampal cell cultures

1 reference

12 December 2020

Activation of group I metabotropic glutamate receptors reduces neuronal apoptosis but increases necrotic cell death in vitro

1 reference

12 December 2020

The Shank family of scaffold proteins

1 reference

12 December 2020

The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate recepto

1 reference

12 December 2020

Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective

1 reference

12 December 2020

Homer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and M-type potassium channels

1 reference

12 December 2020

Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats

1 reference

12 December 2020

Region-specific decline in the expression of metabotropic glutamate receptor 7 mRNA in rat brain during aging

1 reference

12 December 2020

Neuroprotection by group I metabotropic glutamate receptor antagonists in forebrain ischemia of gerbil

1 reference

12 December 2020

Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.

1 reference

12 December 2020

mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors

1 reference

12 December 2020

Methylphenylethynylpyridine (MPEP) Novartis

1 reference

12 December 2020

Anxiolytic-like effects of group I metabotropic glutamate antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats

1 reference

12 December 2020

Changes in metabotropic glutamate receptor expression following spinal cord injury

1 reference

12 December 2020

Activation of metabotropic glutamate receptor 1 accelerates NMDA receptor trafficking

1 reference

12 December 2020

Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer.

1 reference

12 December 2020

Differential roles for mGluR1 and mGluR5 in the persistent prolongation of epileptiform bursts

1 reference

12 December 2020

Glutamate receptor ligands as anxiolytics

1 reference

12 December 2020

Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia.

1 reference

12 December 2020

Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of parkinsonism.

1 reference

12 December 2020

Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices

1 reference

12 December 2020

Inhibitory effects of MPEP, an mGluR5 antagonist, and memantine, an N-methyl-D-aspartate receptor antagonist, on morphine antinociceptive tolerance in mice

1 reference

12 December 2020

Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5

1 reference

12 December 2020

Neuroprotective activity of metabotropic glutamate receptor ligands.

1 reference

12 December 2020

The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice

1 reference

12 December 2020

Metabotropic glutamate 5 receptor blockade alleviates akinesia by normalizing activity of selective basal-ganglia structures in parkinsonian rats.

1 reference

12 December 2020

Modulation of metabotropic glutamate receptors as potential treatment for acute and chronic neurodegenerative disorders

1 reference

12 December 2020

Excitatory aminoacids and epileptic seizures in immature brain.

1 reference

12 December 2020

mGlu5 receptor antagonists: a novel class of anxiolytics?

1 reference

12 December 2020

Opposite influence of MPEP, an mGluR5 antagonist, on the locomotor hyperactivity induced by PCP and amphetamine

1 reference

12 December 2020

Effects of MPEP on locomotion, sensitization and conditioned reward induced by cocaine or morphine

1 reference

12 December 2020

Selective mGlu5 receptor antagonist MTEP attenuates naloxone-induced morphine withdrawal symptoms.

1 reference

12 December 2020

The role of excitatory amino acids and NMDA receptors in traumatic brain injury

1 reference

12 December 2020

Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons

1 reference

12 December 2020

Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes

1 reference

12 December 2020

Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide

1 reference

12 December 2020

Mechanisms underlying developmental changes in the expression of metabotropic glutamate receptors in cultured cerebellar granule cells: homologous desensitization and interactive effects involving N-methyl-D-aspartate receptors.

1 reference

12 December 2020

Metabotropic glutamate receptors are differentially regulated during development

1 reference

12 December 2020

Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat.

1 reference

12 December 2020

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study

1 reference

12 December 2020

Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury.

1 reference

12 December 2020

The modulation of calcium currents by the activation of mGluRs. Functional implications

1 reference

12 December 2020

Inhibition of the electrogenic Na pump underlies delayed depolarization of cortical neurons after mechanical injury or glutamate

1 reference

12 December 2020

Activation of the metabotropic glutamate receptor mGluR5 prevents glutamate toxicity in primary cultures of cerebellar neurons.

1 reference

12 December 2020

Status epilepticus-induced alterations in metabotropic glutamate receptor expression in young and adult rats.

1 reference

12 December 2020

Metabotropic glutamate receptors in the rat nucleus accumbens contribute to amphetamine-induced locomotion.

1 reference

12 December 2020

RGS4 inhibits signaling by group I metabotropic glutamate receptors.

1 reference

12 December 2020

Role of Group I Metabotropic Glutamate Receptors in Traumatic Spinal Cord White Matter Injury

1 reference

12 December 2020

Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors

1 reference

12 December 2020

Metabotropic glutamate receptors: electrophysiological properties and role in plasticity

1 reference

12 December 2020

10.1111/J.1527-3458.2006.00149.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6494124&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6494124&resulttype=core&format=json

14 May 2020

1 reference