(Q24649568)

22 June 2017

title

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia (English)

1 reference

22 June 2017

0 references

W Y Chan

1

1 reference

22 June 2017

D L McKinzie

2

1 reference

22 June 2017

S Bose

3

1 reference

22 June 2017

S N Mitchell

4

1 reference

22 June 2017

J M Witkin

5

1 reference

22 June 2017

R C Thompson

6

1 reference

22 June 2017

A Christopoulos

7

1 reference

22 June 2017

S Lazareno

8

1 reference

22 June 2017

N J M Birdsall

9

1 reference

22 June 2017

F P Bymaster

10

1 reference

22 June 2017

C C Felder

11

1 reference

22 June 2017

language of work or name

English

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publication date

4 August 2008

1 reference

Proceedings of the National Academy of Sciences of the United States of America

22 June 2017

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

22 June 2017

volume

105

1 reference

22 June 2017

issue

31

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22 June 2017

page(s)

10978-10983

1 reference

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

22 June 2017

cites work

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7 April 2017

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Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

7 April 2017

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Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies

7 April 2017

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Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors

7 April 2017

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Functional effects of the muscarinic receptor agonist, xanomeline, at 5-HT1 and 5-HT2 receptors

7 April 2017

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Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

7 April 2017

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In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders

28 September 2017

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Altered hippocampal muscarinic M4, but not M1, receptor expression from subjects with schizophrenia.

28 September 2017

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Towards a muscarinic hypothesis of schizophrenia.

28 September 2017

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28 September 2017

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Subtyping schizophrenia: implications for genetic research

28 September 2017

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Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia

28 September 2017

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Brain cholinergic vulnerability: relevance to behavior and disease

28 September 2017

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Allosterism at muscarinic receptors: ligands and mechanisms

28 September 2017

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28 September 2017

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28 September 2017

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Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists.

28 September 2017

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Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system

28 September 2017

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G protein-coupled receptor allosterism and complexing

28 September 2017

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Schizophrenia: diverse approaches to a complex disease

28 September 2017

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28 September 2017

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Therapeutic opportunities for muscarinic receptors in the central nervous system

28 September 2017

1 reference

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Allosteric interactions at muscarinic cholinoceptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2495016

Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2495016

Effects of central muscarinic-1 receptor stimulation on blood pressure regulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2495016

The distribution of m4 muscarinic acetylcholine receptors in the islands of Calleja and striatum of rats and cynomolgus monkeys

28 September 2017

1 reference

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Determination of [35S]guanosine-5'-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay.

30 May 2018

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Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors

30 May 2018

1 reference

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Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.

30 May 2018

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Association of muscarinic m1 receptor genetic polymorphisms with psychiatric symptoms and cognitive function in schizophrenic patients

30 May 2018

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Association of anticholinergic load with impairment of complex attention and memory in schizophrenia

21 January 2018

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M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies

21 January 2018

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The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance

21 January 2018

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Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane .

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0800567105

Role of hippocampal M1 and M4 muscarinic receptor subtypes in memory consolidation in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0800567105

Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.0800567105

Allosteric Modulation of G Protein–Coupled Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0800567105

Allosteric binding sites on muscarinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0800567105

Asparagine, valine, and threonine in the third extracellular loop of muscarinic receptor have essential roles in the positive cooperativity of strychnine-like allosteric modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0800567105

Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor: more similarities than differences between the structurally divergent agents gallamine and bis(ammonio)alkane-type hexamethylene-bis-[dimethyl-(3

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2495016

Muscarinic and nicotinic receptors synergistically modulate working memory and attention in humans

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2495016

5-HT2A and muscarinic receptors in schizophrenia: a postmortem study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2495016

Changes of cooperativity between N-methylscopolamine and allosteric modulators alcuronium and gallamine induced by mutations of external loops of muscarinic M(3) receptors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2495016

Development of antisera selective for m4 and m5 muscarinic cholinergic receptors: distribution of m4 and m5 receptors in rat brain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2495016

Site-directed mutagenesis reveals two epitopes involved in the subtype selectivity of the allosteric interactions of gallamine at muscarinic acetylcholine receptors

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18678919

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neuroprotection in schizophrenia

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0800567105

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1073/PNAS.0800567105

1 reference

OpenCitations bibliographic resource ID

22 June 2017

0 references

839980

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

839980

1 reference