(Q24654902)

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Klotho and aging

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scholarly article

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Europe PubMed Central

Klotho and aging (English)

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1

object named as

Makoto Kuro-o

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language of work or name

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publication date

October 2009

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Biochimica et Biophysica Acta

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1790

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10

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1049-58

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Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

1 reference

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1 reference

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Suppression of aging in mice by the hormone Klotho

1 reference

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FGF-21 as a novel metabolic regulator

1 reference

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FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis

1 reference

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Overexpression of Plasma Membrane-associated Sialidase Attenuates Insulin Signaling in Transgenic Mice

1 reference

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Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women

1 reference

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Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors

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Association of human aging with a functional variant of klotho

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Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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A C. elegans mutant that lives twice as long as wild type

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7 April 2017

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Functional interaction between beta-catenin and FOXO in oxidative stress signaling

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis

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7 April 2017

The Klotho gene family and the endocrine fibroblast growth factors

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7 April 2017

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

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7 April 2017

Augmented Wnt signaling in a mammalian model of accelerated aging

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7 April 2017

alpha-Klotho as a regulator of calcium homeostasis

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7 April 2017

Klotho converts canonical FGF receptor into a specific receptor for FGF23

1 reference

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7 April 2017

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

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7 April 2017

Genetic influences on oxidative stress and their association with normal cognitive ageing

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7 April 2017

Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system

1 reference

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7 April 2017

FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization

1 reference

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7 April 2017

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

1 reference

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7 April 2017

Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein

1 reference

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7 April 2017

The parathyroid is a target organ for FGF23 in rats

1 reference

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7 April 2017

Regulation of fibroblast growth factor-23 signaling by klotho

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Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo

1 reference

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Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4

1 reference

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7 April 2017

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

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7 April 2017

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

1 reference

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7 April 2017

The plasticity of aging: insights from long-lived mutants

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7 April 2017

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

1 reference

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7 April 2017

Extended longevity in mice lacking the insulin receptor in adipose tissue

1 reference

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7 April 2017

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

1 reference

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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

1 reference

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A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

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7 April 2017

The endocrine regulation of aging by insulin-like signals

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10 May 2017

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

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28 September 2017

Endocrine FGFs and Klothos: emerging concepts

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 September 2017

Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 September 2017

Functionally significant insulin-like growth factor I receptor mutations in centenarians

1 reference

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28 September 2017

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

1 reference

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28 September 2017

A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis

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28 September 2017

Brain IRS2 signaling coordinates life span and nutrient homeostasis

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28 September 2017

Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization

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28 September 2017

Amelioration of progressive renal injury by genetic manipulation of Klotho gene

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28 September 2017

Morphological mechanism of the development of pulmonary emphysema in klotho mice

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28 September 2017

Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging

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28 September 2017

Phosphatonins and the regulation of phosphate homeostasis

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28 September 2017

Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 September 2017

Targeting insulin-like growth factor pathways.

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28 September 2017

The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 September 2017

Regulation of oxidative stress by the anti-aging hormone klotho

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 September 2017

Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23

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28 September 2017

Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 September 2017

Down-regulation and growth inhibitory role of C/EBPalpha in breast cancer

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28 September 2017

FGF23 and disorders of phosphate homeostasis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 September 2017

Calcium absorption across epithelia

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 September 2017

Life extension in the dwarf mouse

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 September 2017

Evolution of the Fgf and Fgfr gene families

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 September 2017

Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 September 2017

The phosphatonin pathway: new insights in phosphate homeostasis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 September 2017

KLOTHO allele status and the risk of early-onset occult coronary artery disease

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28 September 2017

Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation

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28 September 2017

Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia

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28 September 2017

Sequence, structural, functional, and phylogenetic analyses of three glycosidase families

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28 September 2017

Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.

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30 May 2018

Dwarf mice and the ageing process.

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19 June 2018

Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey.

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28 November 2018

Fibroblast growth factor-23 regulates parathyroid hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cells

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28 November 2018

Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice.

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28 November 2018

Identification of a hormonal basis for gallbladder filling.

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28 November 2018

Relationship between polymorphisms G395A in promoter and C1818T in exon 4 of the KLOTHO gene with glucose metabolism and cardiovascular risk factors in Korean women.

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28 November 2018

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.

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28 November 2018

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28 November 2018

Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process

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28 November 2018

Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells

1 reference

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28 November 2018

Klotho reduces apoptosis in experimental ischaemic acute renal failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 November 2018

Impaired regulation of gonadotropins leads to the atrophy of the female reproductive system in klotho-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 November 2018

Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice

1 reference

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28 November 2018

Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 November 2018

Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity

1 reference

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28 November 2018

Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women.

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28 November 2018

Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 November 2018

Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides

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28 November 2018

Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress.

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28 November 2018

Expression of Klotho protein in the inner ear.

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28 November 2018

Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene

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28 November 2018

Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells

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28 November 2018

Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 November 2018

Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 November 2018

Klotho protein protects against endothelial dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743784

28 November 2018

Association between diabetes mellitus and adverse characteristics of breast cancer at presentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elongation of the epiphyseal trabecular bone in transgenic mice carrying a klotho gene locus mutation that leads to a syndrome resembling aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-resolution micro-computed tomography analyses of the abnormal trabecular bone structures in klotho gene mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Snell dwarf mutation Pit1(dw) can increase life span in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Klotho protein deficiency leads to overactivation of mu-calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Klotho gene polymorphisms associated with bone density of aged postmenopausal women

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of sialic acid in insulin action and the insulin resistance of diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Salt-sensitive hypertension in transgenic mice overexpressing Na(+)-proton exchanger

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Klotho gene polymorphism and male bone mass

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19230844

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Klotho gene family as a regulator of endocrine fibroblast growth factors

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAGEN.2009.02.005

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.BBAGEN.2009.02.005

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

0 references

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