(Q24655332)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18420578%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

title

Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18420578%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18420578%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Alan Fairlamb

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18420578%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

William Nigel Hunter

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18420578%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

author name string

Paul K Fyfe

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18420578%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

language of work or name

English

0 references

publication date

17 April 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18420578%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

5 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18420578%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

volume

283

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18420578%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

issue

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18420578%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

page(s)

17672-17680

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18420578%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

5 January 2020

PyMOL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pmc&rettype=xml&id=PMC2427367

cites work

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Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes

7 April 2017

1 reference

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A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity

7 April 2017

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Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata

7 April 2017

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Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function

7 April 2017

1 reference

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Large conformational changes in the catalytic cycle of glutathione synthase

7 April 2017

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The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins

7 April 2017

1 reference

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The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I

7 April 2017

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Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

7 April 2017

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A pseudo-michaelis quaternary complex in the reverse reaction of a ligase: structure of Escherichia coli B glutathione synthetase complexed with ADP, glutathione, and sulfate at 2.0 A resolution

7 April 2017

1 reference

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Scaling and assessment of data quality

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

7 April 2017

1 reference

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Coot: model-building tools for molecular graphics

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

The CCP4 suite: programs for protein crystallography

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Structure validation by Calpha geometry: phi,psi and Cbeta deviation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Use of TLS parameters to model anisotropic displacements in macromolecular refinement

7 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

7 April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Maximum-likelihood density modification

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Efficient anisotropic refinement of macromolecular structures using FFT

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Automated MAD and MIR structure solution

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

7 April 2017

1 reference

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Drug resistance in leishmaniasis

7 April 2017

1 reference

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Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.

7 April 2017

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Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis

28 September 2017

1 reference

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Drugs and drug resistance in African trypanosomiasis

28 September 2017

1 reference

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Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase

28 September 2017

1 reference

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Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major

28 September 2017

1 reference

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Enzyme inhibitors as chemical tools to study enzyme catalysis: rational design, synthesis, and applications

28 September 2017

1 reference

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Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia

28 September 2017

1 reference

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Trypanothione biosynthesis in Leishmania major

28 September 2017

1 reference

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Trypanothione synthesis in crithidia revisited.

28 September 2017

1 reference

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Validation of Trypanosoma brucei trypanothione synthetase as drug target

28 September 2017

1 reference

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The CHAP domain: a large family of amidases including GSP amidase and peptidoglycan hydrolases

28 September 2017

1 reference

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Amidase domains from bacterial and phage autolysins define a family of gamma-D,L-glutamate-specific amidohydrolases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Polyamine metabolism as chemotherapeutic target in protozoan parasites

28 September 2017

1 reference

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A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Polyamines as targets for therapeutic intervention

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Metabolism and functions of trypanothione in the Kinetoplastida

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

Protozoan genomics for drug discovery.

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801850200

Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801850200

Properties of trypanothione synthetase from Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801850200

Protein Identification and Analysis Tools on the ExPASy Server

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801850200

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801850200

MOLREP: an Automated Program for Molecular Replacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801850200

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801850200

A solution for the best rotation to relate two sets of vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801850200

A comprehensive and non-redundant database of protein domain movements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801850200

Genomic analysis of the eukaryotic protein kinase superfamily: a perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801850200

Function of conserved residues of human glutathione synthetase: implications for the ATP-grasp enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801850200

High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801850200

Design, synthesis, and biological evaluation of phosphinopeptides against Trypanosoma cruzi targeting trypanothione biosynthesis.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2427367

28 November 2018

Cutaneous leishmaniasis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18420578

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Catalytic mechanism in papain family of cysteine peptidases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18420578

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dissection of glutathionylspermidine synthetase/amidase from Escherichia coli into autonomously folding and functional synthetase and amidase domains

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18420578

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M801850200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18420578%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18420578%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference