(Q24810937)

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In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane

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scholarly article

1 reference

Europe PubMed Central

5 July 2017

In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane (English)

1 reference

Europe PubMed Central

5 July 2017

Melvin E. Andersen

object named as

Melvin E Andersen

2

0 references

author name string

Ivan D Dobrev

1

1 reference

Europe PubMed Central

5 July 2017

Raymond S H Yang

3

1 reference

Europe PubMed Central

5 July 2017

language of work or name

0 references

publication date

1 October 2002

1 reference

Europe PubMed Central

5 July 2017

Environmental Health Perspectives

1 reference

Europe PubMed Central

5 July 2017

110

1 reference

Europe PubMed Central

5 July 2017

10

1 reference

Europe PubMed Central

5 July 2017

1031-1039

1 reference

Europe PubMed Central

5 July 2017

Biological monitoring of workers exposed to ethylbenzene and co-exposed to xylene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Renal toxicity and carcinogenicity of trichloroethylene: key results, mechanisms, and controversies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Exposure assessment of trichloroethylene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Evaluating noncancer effects of trichloroethylene: dosimetry, mode of action, and risk assessment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Physiologically based pharmacokinetic models for trichloroethylene and its oxidative metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Metabolism of trichloroethylene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Estimation of toxicity of chemical mixtures through modeling of chemical interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Assessing the relevance of rodent data on chemical interactions for health risk assessment purposes: a case study with dichloromethane-toluene mixture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

PBPK modeling/Monte Carlo simulation of methylene chloride kinetic changes in mice in relation to age and acute, subchronic, and chronic inhalation exposure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Physiologically based pharmacokinetic analyses of simple mixtures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

A physiologically based simulation approach for determining metabolic constants from gas uptake data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Trichloroethylene cancer risk: simplified calculation of PBPK-based MCLs for cytotoxic end points

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Variability in biological monitoring of organic solvent exposure. II. Application of a population physiological model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Difference in uptake, elimination, and metabolism in exposure to trichloroethylene, 1,1,1-trichloroethane and tetrachloroethylene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

Kinetics of tetrachloroethylene in volunteers; influence of exposure concentration and work load

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 September 2017

The role of glutathione conjugation in the development of kidney tumours in rats exposed to trichloroethylene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

30 May 2018

Alternatives for a risk assessment on chronic noncancer effects from oral exposure to trichloroethylene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

30 May 2018

Biotransformation of trichloroethene: dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

30 May 2018

Physiologically based pharmacodynamic modeling of an interaction threshold between trichloroethylene and 1,1-dichloroethylene in Fischer 344 rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

30 May 2018

Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

30 May 2018

Physiologically based modeling of the toxicokinetic interaction between toluene and m-xylene in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

30 May 2018

Chloroethylene mixtures: pharmacokinetic modeling and in vitro metabolism of vinyl chloride, trichloroethylene, and trans-1,2-dichloroethylene in rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

30 May 2018

A physiologically based toxicokinetic description of the metabolism of inhaled gases and vapors: Analysis at steady state*1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

30 May 2018

Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

30 May 2018

Physiologically based pharmacokinetic modeling with methylchloroform: implications for interspecies, high dose/low dose, and dose route extrapolations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

30 May 2018

A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 November 2018

Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 November 2018

Study on the cytochrome P-450- and glutathione-dependent biotransformation of trichloroethylene in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 November 2018

A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 November 2018

Application of biological monitoring to the quantitative exposure assessment for neuropsychological effect by chronic exposure to organic solvents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 November 2018

A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 November 2018

Exploration of an interaction threshold for the joint toxicity of trichloroethylene and 1,1-dichloroethylene: utilization of a PBPK model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 November 2018

In vivo and in vitro studies of perchloroethylene metabolism for physiologically based pharmacokinetic modeling in rats, mice, and humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1241030

28 November 2018

Experimental human exposures to tetrachloroethylene vapor and elimination in breath after inhalation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12361929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics and metabolism of inhaled methyl chloroform (1,1,1-trichloroethane) in male volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12361929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of tetrachloroethylene*1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12361929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologically-based pharmacokinetic modeling of a mixture of toluene and xylene in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/12361929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variability in biological exposure indices using physiologically based pharmacokinetic modeling and Monte Carlo simulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12361929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethnic differences in biological monitoring of several organic solvents. I. Human exposure experiment

1 reference

https://pubmed.ncbi.nlm.nih.gov/12361929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione-dependent bioactivation of haloalkenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12361929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of measured end-points in demonstrating the occurrence of interactions: a case study with methylchloroform and m-xylene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12361929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uncertainties in physiologically based pharmacokinetic models caused by several input parameters

1 reference

https://pubmed.ncbi.nlm.nih.gov/12361929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gas Uptake Inhalation Techniques and the Rates of Metabolism of Chloromethanes, Chloroethanes, and Chloroethylenes in the Rat

1 reference

https://api.crossref.org/works/10.1289%2FEHP.021101031

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1289/EHP.021101031

1 reference

Europe PubMed Central

5 July 2017

1 reference

Europe PubMed Central

5 July 2017

1 reference

Europe PubMed Central

5 July 2017

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