(Q26739009)

title

Fatty old hearts: role of cardiac lipotoxicity in age-related cardiomyopathy (English)

0 references

1 reference

Konstantinos Drosatos

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27558317%20AND%20SRC:MED&resulttype=core&format=json

Pathobiology of aging & age related diseases

13 June 2020

author name string

Konstantinos Drosatos

series ordinal

1

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language of work or name

English

0 references

publication date

2016

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published in

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27558317%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27558317%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

0

0 references

page(s)

32221

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27558317%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial 4.0 International

13 June 2020

copyright license

start time

1 January 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity

28 September 2017

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Cardiac lipotoxicity: molecular pathways and therapeutic implications

28 September 2017

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Cardiomyocyte aldose reductase causes heart failure and impairs recovery from ischemia.

28 September 2017

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Lipid metabolism and toxicity in the heart

28 September 2017

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Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure

28 September 2017

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Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation

28 September 2017

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ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.

28 September 2017

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Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy.

28 September 2017

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Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation

28 September 2017

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PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation.

28 September 2017

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Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype

28 September 2017

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Cardiac aging in mice and humans: the role of mitochondrial oxidative stress

28 September 2017

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The role of inflammatory and fibrogenic pathways in heart failure associated with aging.

28 September 2017

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Myocardial fatty acid metabolism in health and disease

28 September 2017

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DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity

28 September 2017

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Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.

28 September 2017

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Structural basis of protein kinase C isoform function

28 September 2017

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Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

28 September 2017

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Decreased maximal heart rate with aging is related to reduced {beta}-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate

28 September 2017

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The PPAR trio: regulators of myocardial energy metabolism in health and disease

28 September 2017

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Cardiolipin, the heart of mitochondrial metabolism.

28 September 2017

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28 September 2017

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28 September 2017

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Role of cardiolipin alterations in mitochondrial dysfunction and disease

28 September 2017

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28 September 2017

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28 September 2017

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Protection in the aged heart: preventing the heart-break of old age?

28 September 2017

1 reference

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Triglyceride accumulation protects against fatty acid-induced lipotoxicity

28 September 2017

1 reference

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Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease

28 September 2017

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Emerging roles of PPARs in inflammation and immunity

28 September 2017

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Acute and chronic adaptation to hemodynamic overload and ischemia in the aged heart

28 September 2017

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Aging selectively decreases oxidative capacity in rat heart interfibrillar mitochondria

28 September 2017

1 reference

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28 September 2017

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The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification

28 September 2017

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28 September 2017

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Use of a PCR-based method to characterize protein kinase C isoform expression in cardiac cells

28 September 2017

1 reference

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28 September 2017

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28 September 2017

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Phosphorylation and Activation of β-Adrenergic Receptor Kinase by Protein Kinase C

31 May 2018

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Systolic and diastolic heart failure in the community.

31 May 2018

1 reference

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Impact of aging on substrate metabolism by the human heart

21 January 2018

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CD36 expression contributes to age-induced cardiomyopathy in mice

21 January 2018

1 reference

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Comprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart

21 January 2018

1 reference

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A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated wi

21 January 2018

1 reference

https://api.crossref.org/works/10.3402%2FPBA.V6.32221

Decreased contractile and metabolic reserve in peroxisome proliferator-activated receptor-alpha-null hearts can be rescued by increasing glucose transport and utilization

21 January 2018

1 reference

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Decreased longevity and enhancement of age-dependent lesions in mice lacking the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha).

21 January 2018

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Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse

21 January 2018

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Unchanged G-protein-coupled receptor kinase activity in the aging human heart

21 January 2018

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Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin

21 January 2018

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Metabolic remodeling in the aging heart

21 January 2018

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https://api.crossref.org/works/10.3402%2FPBA.V6.32221

Effect of aging on formation of reactive oxygen species by mitochondria of rat heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.3402%2FPBA.V6.32221

Preservation of cardiolipin content during aging in rat heart interfibrillar mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.3402%2FPBA.V6.32221

Enhanced modification of cardiolipin during ischemia in the aged heart

21 January 2018

1 reference

https://api.crossref.org/works/10.3402%2FPBA.V6.32221

Mitochondrial DNA deletions and the aging heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.3402%2FPBA.V6.32221

Role of oxidative stress in cardiac dysfunction of PPARα−/− mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3402%2FPBA.V6.32221

Tempol prevents cardiac oxidative damage and left ventricular dysfunction in the PPAR-α KO mouse

21 January 2018

1 reference

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Effects of aging on activities of mitochondrial electron transport chain complexes and oxidative damage in rat heart

21 January 2018

1 reference

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Hypoxemia is associated with mitochondrial DNA damage and gene induction. Implications for cardiac disease

28 November 2018

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12 December 2020

Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart

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12 December 2020

Oxygen consumption in adult and AGED C57BL/6J mice during acute treadmill exercise of different intensity

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12 December 2020

Aging-induced decrease in the PPAR-alpha level in hearts is improved by exercise training

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12 December 2020

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

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12 December 2020

Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats

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12 December 2020

Tolerance to ischemia and hypoxia is reduced in aged human myocardium

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12 December 2020

Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging

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12 December 2020

Atorvastatin may delay cardiac aging by upregulating peroxisome proliferator-activated receptors in rats

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12 December 2020

Deletion of peroxisome proliferator-activated receptor-alpha induces an alteration of cardiac functions

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12 December 2020

Peroxidative damage to cardiac mitochondria: cytochrome oxidase and cardiolipin alterations

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12 December 2020

Type 5 adenylyl cyclase disruption increases longevity and protects against stress

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12 December 2020

Age- and sex-dependent alterations in protein kinase C (PKC) and extracellular regulated kinase 1/2 (ERK1/2) in rat myocardium

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12 December 2020

Cardiolipin-dependent decrease of cytochrome c oxidase activity in heart mitochondria from hypothyroid rats

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12 December 2020

Molecular heterogeneity of protein kinase C expression in human ventricle

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12 December 2020

Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy

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12 December 2020

Peroxisome proliferator-activated receptor alpha down-regulation is associated with enhanced ceramide levels in age-associated cardiac hypertrophy

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12 December 2020

Varied prevalence of age-associated mitochondrial DNA deletions in different species and tissues: a comparison between human and rat

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12 December 2020

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

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12 December 2020

Age-dependent decrease in the cytochrome c oxidase activity and changes in phospholipids in rat-heart mitochondria

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12 December 2020

Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity

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12 December 2020

Protein kinase C isoform expression in normal and failing rabbit hearts

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12 December 2020

Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria

1 reference

12 December 2020

Age-dependent decline in the cytochrome c oxidase activity in rat heart mitochondria: role of cardiolipin

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12 December 2020

The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function

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12 December 2020

Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction

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12 December 2020

Calcium-stimulated phosphorylation of MAP-2 in pancreatic betaTC3-cells is mediated by Ca2+/calmodulin-dependent kinase II

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.3402/PBA.V6.32221

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27558317%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27558317%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

PubMed publication ID

27558317

2 references