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Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites

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18 July 2021

Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites (English)

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18 July 2021

metabolic engineering

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19 September 2019

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22 October 2019

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7 November 2019

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PubMed publication ID

Artemisia annua

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subject heading

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Artemisia annua

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Ery O. Fukushima

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27250562%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Toshiya Muranaka

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27250562%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Paskorn Muangphrom

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27250562%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Hikaru Seki

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27250562%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

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publication date

July 2016

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1 July 2016

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22 June 2019

30 June 2019

19 September 2019

22 October 2019

4 November 2019

7 November 2019

28 May 2020

18 July 2021

Journal of Natural Medicines

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27250562%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

70

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27250562%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

3

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27250562%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

318-334

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27250562%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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Creative Commons Attribution 4.0 International

8 references

Europe PubMed Central

22 June 2019

Europe PubMed Central

30 June 2019

Europe PubMed Central

19 September 2019

Europe PubMed Central

22 October 2019

Europe PubMed Central

4 November 2019

Europe PubMed Central

7 November 2019

Europe PubMed Central

28 May 2020

Europe PubMed Central

18 July 2021

copyright status

0 references

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Distinct biochemical properties of human serine hydroxymethyltransferase compared with the Plasmodium enzyme: implications for selective inhibition

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A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

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Artemisinin: discovery from the Chinese herbal garden

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Nicotiana benthamiana as a production platform for artemisinin precursors

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7 April 2017

Artemisinin Resistance in Plasmodium falciparum Malaria

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High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli

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Production of the antimalarial drug precursor artemisinic acid in engineered yeast

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Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities

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A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase

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A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites

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Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach

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Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum

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Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

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Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target

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A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

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Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum

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The use of combining ability analysis to identify elite parents for Artemisia annua F1 hybrid production

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7 April 2017

High-level semi-synthetic production of the potent antimalarial artemisinin

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Dried whole plant Artemisia annua as an antimalarial therapy

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7 April 2017

Amorpha-4,11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate

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7 April 2017

Amorpha-4,11-diene synthase of Artemisia annua: cDNA isolation and bacterial expression of a terpene synthase involved in artemisinin biosynthesis

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7 April 2017

Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L

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7 April 2017

Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis

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7 April 2017

The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin

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7 April 2017

Genetic Transformation of Artemisia carvifolia Buch with rol Genes Enhances Artemisinin Accumulation

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7 April 2017

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance

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Dual symbiosis between Piriformospora indica and Azotobacter chroococcum enhances the artemisinin content in Artemisia annua L.

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28 September 2017

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

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28 September 2017

Plasmodium falciparum kelch 13: a potential molecular marker for tackling artemisinin-resistant malaria parasites

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28 September 2017

A Unique Plasmodium falciparum K13 Gene Mutation in Northwest Ethiopia

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28 September 2017

The discovery of artemisinin and the Nobel Prize in Physiology or Medicine

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Expression of β-glucosidase increases trichome density and artemisinin content in transgenic Artemisia annua plants

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28 September 2017

Artemisinin resistance at the China-Myanmar border and association with mutations in the K13 propeller gene

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Variations in key artemisinic and other metabolites throughout plant development in Artemisia annua L. for potential therapeutic use.

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Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

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Changes in key constituents of clonally propagated Artemisia annua L. during preparation of compressed leaf tablets for possible therapeutic use.

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28 September 2017

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28 September 2017

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28 September 2017

Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model.

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28 September 2017

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28 September 2017

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

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28 September 2017

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28 September 2017

Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

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28 September 2017

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

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Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia

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28 September 2017

The effect of roots and media constituents on trichomes and artemisinin production in Artemisia annua L.

1 reference

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28 September 2017

Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study

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28 September 2017

Metabolic engineering of microorganisms for the synthesis of plant natural products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

A major genome region underlying artemisinin resistance in malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

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28 September 2017

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Survey of artemisinin production by diverse Artemisia species in northern Pakistan

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28 September 2017

The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

The molecular mechanism of action of artemisinin--the debate continues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

The genetic map of Artemisia annua L. identifies loci affecting yield of the antimalarial drug artemisinin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Isolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha-4,11-diene synthase gene, a key gene of artemisinin biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Salicylic acid activates artemisinin biosynthesis in Artemisia annua L.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Artemisia annua as a self-reliant treatment for malaria in developing countries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

The genetics of artemisinin content in Artemisia annua L. and the breeding of high yielding cultivars

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Experimental design-aided systematic pathway optimization of glucose uptake and deoxyxylulose phosphate pathway for improved amorphadiene production.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 September 2017

Enhanced artemisinin yield by expression of rol genes in Artemisia annua

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

31 May 2018

Overexpression of artemisinic aldehyde Δ11 (13) reductase gene-enhanced artemisinin and its relative metabolite biosynthesis in transgenic Artemisia annua L.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

31 May 2018

An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

31 May 2018

The jasmonate-responsive AP2/ERF transcription factors AaERF1 and AaERF2 positively regulate artemisinin biosynthesis in Artemisia annua L.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

31 May 2018

The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

31 May 2018

Tissue specificity and developmental pattern of amorpha-4,11-diene synthase (ADS) proved by ADS promoter-driven GUS expression in the heterologous plant, Arabidopsis thaliana

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

31 May 2018

In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

31 May 2018

Randomised comparative study of mefloquine, qinghaosu, and pyrimethamine-sulfadoxine in patients with falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

31 May 2018

Artemisia species: From traditional medicines to modern antimalarials--and back again

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Discovery of Artemisinin (Qinghaosu)

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

The molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis in Artemisia annua

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Reproductive Development Modulates Gene Expression and Metabolite Levels with Possible Feedback Inhibition of Artemisinin in Artemisia annua

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Trichome-specific expression of the amorpha-4,11-diene 12-hydroxylase (cyp71av1) gene, encoding a key enzyme of artemisinin biosynthesis in Artemisia annua, as reported by a promoter-GUS fusion.

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

The metabolite chemotype of Nicotiana benthamiana transiently expressing artemisinin biosynthetic pathway genes is a function of CYP71AV1 type and relative gene dosage

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

The activity of the artemisinic aldehyde Δ11(13) reductase promoter is important for artemisinin yield in different chemotypes of Artemisia annua L.

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Two distinct and competitive pathways confer the cellcidal actions of artemisinins

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Making artemisinin

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Agrobacterium tumefaciens-mediated transformation of Artemisia annua L. and regeneration of transgenic plants.

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Overexpression of the cytochrome P450 monooxygenase (cyp71av1) and cytochrome P450 reductase (cpr) genes increased artemisinin content in Artemisia annua (Asteraceae).

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Nutrient deficiency in the production of artemisinin, dihydroartemisinic acid, and artemisinic acid in Artemisia annua L.

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Effects of overexpression of AaWRKY1 on artemisinin biosynthesis in transgenic Artemisia annua plants

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

AaORA, a trichome-specific AP2/ERF transcription factor of Artemisia annua, is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance to Botrytis cinerea

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in Artemisia annua plants.

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Methyl jasmonate and miconazole differently affect arteminisin production and gene expression in Artemisia annua suspension cultures.

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

High-level production of amorpha-4,11-diene in a two-phase partitioning bioreactor of metabolically engineered Escherichia coli

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Enhancing isoprenoid production through systematically assembling and modulating efflux pumps in Escherichia coli

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Efflux transporter engineering markedly improves amorphadiene production in Escherichia coli.

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Engineering Escherichia coli for production of functionalized terpenoids using plant P450s

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3).

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae.

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Effects of vegetative and flowering stages on the biosynthesis of artemisinin in Artemisia species

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Determination of artemisinin in Artemisia sieberi and anticoccidial effects of the plant extract in broiler chickens

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Volatile components of four Ethiopian Artemisia species extracts and their in vitro antitrypanosomal and cytotoxic activities

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

In vitro antiplasmodial and phytochemical study of five Artemisia species from Iran and in vivo activity of two species

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Molecular dynamics of interactions between rigid and flexible antifolates and dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium falciparum.

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

A survey of artemisinic and dihydroartemisinic acid contents in glasshouse and global field-grown populations of the artemisinin-producing plant Artemisia annua L

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Comparative functional analysis of CYP71AV1 natural variants reveals an important residue for the successive oxidation of amorpha-4,11-diene

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

The discovery of Qinghaosu (artemisinin) as an effective anti-malaria drug: A unique China story

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 November 2018

Cloning and characterization of trichome-specific promoter of cpr71av1 gene involved in artemisinin biosynthesis in Artemisia annua L.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 November 2018

Artemisinin production by shoot regeneration of Artemisia annua L. using thidiazuron.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 November 2018

The in vitro anti-plasmodial and in vivo anti-malarial efficacy of combinations of some medicinal plants used traditionally for treatment of malaria by the Meru community in Kenya

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935751

28 November 2018

Cloning and characterization of trichome-specific promoter of cpr71av1 gene involved in artemisinin biosynthesis in Artemisia annua L

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

21 January 2018

Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27250562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclization mechanism of amorpha-4,11-diene synthase, a key enzyme in artemisinin biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27250562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/27250562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic engineering of chloroplasts for artemisinic acid biosynthesis and impact on plant growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/27250562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New orally active amino- and hydroxy-functionalized 11-azaartemisinins and their derivatives with high order of antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27250562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factors influencing Agrobacterium tumefaciens -mediated transformation of Artemisia annua L

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo transformations of artemisinic acid in Artemisia annua plants

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation of high artemisinin-yielding clones of Artemisia annua

1 reference

https://api.crossref.org/works/10.1007%2FS11418-016-1008-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1007/S11418-016-1008-Y

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27250562%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Dimensions Publication ID

0 references

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27250562%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27250562%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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