(Q41925015)

14 October 2017

title

An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites (English)

1 reference

14 October 2017

1 reference

3

1 reference

14 October 2017

12

1 reference

14 October 2017

Rudi Oliveira

1

0 references

Francisca Lopes

object named as

Francisca Lopes

11

0 references

Philip J Rosenthal

8

object named as

Philip J Rosenthal

1 reference

14 October 2017

Ana S Newton

2

1 reference

14 October 2017

Daniela Miranda

4

1 reference

14 October 2017

Richard K Amewu

5

1 reference

14 October 2017

Abhishek Srivastava

6

1 reference

14 October 2017

Jiri Gut

7

1 reference

14 October 2017

Paul M O'Neill

9

1 reference

14 October 2017

Stephen A Ward

10

1 reference

14 October 2017

publication date

12 July 2013

1 reference

14 October 2017

1 reference

14 October 2017

volume

8

1 reference

14 October 2017

issue

9

1 reference

14 October 2017

page(s)

1528-1536

1 reference

Global malaria mortality between 1980 and 2010: a systematic analysis

14 October 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Malaria combination therapies: advantages and shortcomings.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Artemisinin Resistance in Plasmodium falciparum Malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Hybrid molecules with a dual mode of action: dream or reality?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

A medicinal chemistry perspective on artemisinin and related endoperoxides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Selection of a trioxaquine as an antimalarial drug candidate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Dispiro-1,2,4-trioxane analogues of a prototype dispiro-1,2,4-trioxolane: mechanistic comparators for artemisinin in the context of reaction pathways with iron(II).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

On the molecular mechanism of chloroquine's antimalarial action

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Investigating the antimalarial action of 1,2,4-trioxolanes with fluorescent chemical probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Falcipains and other cysteine proteases of malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Synthesis of tetrasubstituted ozonides by the Griesbaum coozonolysis reaction: diastereoselectivity and functional group transformations by post-ozonolysis reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity ‡

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Falcipain inhibition as a promising antimalarial target

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Pharmacokinetics and pharmacodynamics of endoperoxide antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Development and validation of a genetic algorithm for flexible docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

7 January 2021

Artemisinin resistance: current status and scenarios for containment

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

7 January 2021

Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

7 January 2021

Broadly applicable synthesis of 1,2,4,5-tetraoxanes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300202

7 January 2021

Identifiers

DOI

10.1002/CMDC.201300202

1 reference

14 October 2017

1 reference