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How specific is CRISPR/Cas9 really?
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scholarly article
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title
How specific is CRISPR/Cas9 really?
(English)
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main subject
CRISPR
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Cas9
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author name string
Henriette O'Geen
series ordinal
1
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Abigail S Yu
series ordinal
2
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David J Segal
series ordinal
3
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language of work or name
English
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publication date
December 2015
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published in
Current Opinion in Chemical Biology
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volume
29
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page(s)
72-8
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cites work
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
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7 April 2017
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
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7 April 2017
Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9
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7 April 2017
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
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7 April 2017
RNA-guided gene activation by CRISPR-Cas9-based transcription factors
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7 April 2017
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
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7 April 2017
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
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7 April 2017
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
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7 April 2017
CRISPR RNA-guided activation of endogenous human genes
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7 April 2017
DNA targeting specificity of RNA-guided Cas9 nucleases
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PubMed Central
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7 April 2017
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
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7 April 2017
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
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7 April 2017
Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing
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28 September 2017
Sequence determinants of improved CRISPR sgRNA design
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28 September 2017
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.
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PubMed Central
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28 September 2017
In vivo genome editing using Staphylococcus aureus Cas9
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PubMed Central
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28 September 2017
Functional annotation of native enhancers with a Cas9-histone demethylase fusion.
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28 September 2017
Target specificity of the CRISPR-Cas9 system.
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28 September 2017
A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture.
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28 September 2017
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
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28 September 2017
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
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28 September 2017
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.
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28 September 2017
Protospacer adjacent motif (PAM)-distal sequences engage CRISPR Cas9 DNA target cleavage.
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PubMed Central
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28 September 2017
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.
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28 September 2017
Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.
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28 September 2017
Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs
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28 September 2017
CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing
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PubMed Central
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28 September 2017
CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences
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PubMed Central
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28 September 2017
Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease.
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PubMed Central
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28 September 2017
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4684463
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28 September 2017
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4684463
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28 September 2017
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.
1 reference
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PubMed Central
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28 September 2017
Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4684463
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28 September 2017
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases.
1 reference
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PubMed Central
reference URL
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28 September 2017
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
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PubMed Central
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28 September 2017
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4684463
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28 September 2017
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4684463
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28 September 2017
An unbiased genome-wide analysis of zinc-finger nuclease specificity
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PubMed Central
reference URL
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28 September 2017
Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4684463
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31 May 2018
DNA recombination. Recombination initiation maps of individual human genomes
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4684463
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31 May 2018
Flexible guide-RNA design for CRISPR applications using Protospacer Workbench.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4684463
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28 November 2018
Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4684463
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28 November 2018
Identifiers
DOI
10.1016/J.CBPA.2015.10.001
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1615044
OpenCitations bibliographic resource ID
1615044
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1615044
PMCID
4684463
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1615044
PubMed ID
26517564
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1615044
ResearchGate publication ID
283447587
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