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Substrate recognition and function of the R2TP complex in response to cellular stress
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Europe PubMed Central
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4341119
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767478%20AND%20SRC:MED&resulttype=core&format=json
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2 March 2020
review article
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Europe PubMed Central
title
Substrate recognition and function of the R2TP complex in response to cellular stress
(English)
2 references
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PubMed
stated in
Europe PubMed Central
PMC publication ID
4341119
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767478%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 March 2020
author
Patrick von Morgen
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1
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Europe PubMed Central
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4341119
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767478%20AND%20SRC:MED&resulttype=core&format=json
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2 March 2020
Zuzana Hořejší
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2
1 reference
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Europe PubMed Central
PMC publication ID
4341119
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767478%20AND%20SRC:MED&resulttype=core&format=json
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2 March 2020
Libor Macůrek
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3
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Europe PubMed Central
PMC publication ID
4341119
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767478%20AND%20SRC:MED&resulttype=core&format=json
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2 March 2020
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Zuzana Hořejší
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2
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Libor Macurek
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3
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English
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publication date
25 February 2015
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Europe PubMed Central
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4341119
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retrieved
2 March 2020
published in
Frontiers in Genetics
2 references
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Crossref
stated in
Europe PubMed Central
PMC publication ID
4341119
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767478%20AND%20SRC:MED&resulttype=core&format=json
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2 March 2020
volume
6
2 references
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PubMed
stated in
Europe PubMed Central
PMC publication ID
4341119
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767478%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 March 2020
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69
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PubMed
stated in
Europe PubMed Central
PMC publication ID
4341119
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767478%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 March 2020
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A well-connected and conserved nucleoplasmic helicase is required for production of box C/D and H/ACA snoRNAs and localization of snoRNP proteins.
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7 April 2017
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7 April 2017
The DNA damage response: putting checkpoints in perspective
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7 April 2017
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Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks
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A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
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7 April 2017
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
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Sno storm in the nucleolus: new roles for myriad small RNPs
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Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases
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Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control
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DNA binding properties of the actin-related protein Arp8 and its role in DNA repair
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Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2
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28 September 2017
Heat shock protein 90 inhibitors in non-small-cell lung cancer
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Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases
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28 September 2017
Drosophila Spag is the homolog of RNA polymerase II-associated protein 3 (RPAP3) and recruits the heat shock proteins 70 and 90 (Hsp70 and Hsp90) during the assembly of cellular machineries
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28 September 2017
Protein kinase CK2 is required for the recruitment of 53BP1 to sites of DNA double-strand break induced by radiomimetic drugs.
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28 September 2017
Chaperone-like activity of the AAA+ proteins Rvb1 and Rvb2 in the assembly of various complexes
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The emergence of the conserved AAA+ ATPases Pontin and Reptin on the signaling landscape
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
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28 September 2017
Chemical proteomics and functional proteomics strategies for protein kinase inhibitor validation and protein kinase substrate identification: applications to protein kinase CK2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
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28 September 2017
The ATPase activity of reptin is required for its effects on tumor cell growth and viability in hepatocellular carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
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28 September 2017
Kinase CK2 inhibition: an update.
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
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28 September 2017
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
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28 September 2017
Conformational transitions regulate the exposure of a DNA-binding domain in the RuvBL1-RuvBL2 complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
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28 September 2017
Mechanism of the AAA+ ATPases pontin and reptin in the biogenesis of H/ACA RNPs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
A role for chromatin remodellers in replication of damaged DNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
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28 September 2017
Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
First identification of small-molecule inhibitors of Pontin by combining virtual screening and enzymatic assay
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Hsp90 molecular chaperone inhibitors: are we there yet?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Expression and therapeutic relevance of heat-shock protein 90 in pancreatic endocrine tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
ATM and the molecular pathogenesis of ataxia telangiectasia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
The R2TP complex: discovery and functions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
ATR signalling: more than meeting at the fork
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
The multifaceted proteins Reptin and Pontin as major players in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Emergence of protein kinase CK2 as a key target in cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
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28 September 2017
New insights into the biogenesis of nuclear RNA polymerases?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Rvb1-Rvb2: essential ATP-dependent helicases for critical complexes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
RVB1/RVB2: running rings around molecular biology
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Architecture of the pontin/reptin complex, essential in the assembly of several macromolecular complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Pontin and reptin, two related ATPases with multiple roles in cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
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28 September 2017
Orchestration of chromatin-based processes: mind the TRRAP.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Control of transcription by Pontin and Reptin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
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28 September 2017
Crystal structure of the human AAA+ protein RuvBL1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Proteasomes and their associated ATPases: a destructive combination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Heat shock proteins in cancer: chaperones of tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
The role of SMG-1 in nonsense-mediated mRNA decay.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Sick chaperones, cellular stress, and disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Tetratricopeptide repeat cochaperones in steroid receptor complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Conserved arginine residues implicated in ATP hydrolysis, nucleotide-sensing, and inter-subunit interactions in AAA and AAA+ ATPases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Box C/D snoRNA-associated proteins: two pairs of evolutionarily ancient proteins and possible links to replication and transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
The AAA team: related ATPases with diverse functions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase. Implications for heat shock in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
28 September 2017
Nutritional status modulates box C/D snoRNP biogenesis by regulated subcellular relocalization of the R2TP complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
31 May 2018
The stability of the small nucleolar ribonucleoprotein (snoRNP) assembly protein Pih1 in Saccharomyces cerevisiae is modulated by its C terminus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
31 May 2018
The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4341119
retrieved
31 May 2018
(1)H, (15)N and (13)C resonance assignments of the two TPR domains from the human RPAP3 protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.3389%2FFGENE.2015.00069
retrieved
21 January 2018
Oligomeric assembly and interactions within the human RuvB-like RuvBL1 and RuvBL2 complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.3389%2FFGENE.2015.00069
retrieved
21 January 2018
HCLK2 is required for activity of the DNA damage response kinase ATR.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.3389%2FFGENE.2015.00069
retrieved
21 January 2018
Hsp90 inhibition enhances PI-3 kinase inhibition and radiosensitivity in glioblastoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.3389%2FFGENE.2015.00069
retrieved
21 January 2018
HSP90 and the R2TP co-chaperone complex: building multi-protein machineries essential for cell growth and gene expression
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25767478
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25767478
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3389/FGENE.2015.00069
1 reference
stated in
Europe PubMed Central
PMC publication ID
4341119
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767478%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 March 2020
PMC publication ID
4341119
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
4341119
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767478%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 March 2020
PubMed publication ID
25767478
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
4341119
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767478%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 March 2020
ResearchGate publication ID
273951891
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