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Minireview: From the bench, toward the clinic: therapeutic opportunities for cannabinoid receptor modulation
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Europe PubMed Central
title
Minireview: From the bench, toward the clinic: therapeutic opportunities for cannabinoid receptor modulation
(English)
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PubMed
main subject
CNR2
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cannabinoids
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cannabinoid receptor
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author name string
Robert P. Picone
series ordinal
1
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Crossref
Debra A. Kendall
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2
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language of work or name
English
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PubMed
publication date
June 2015
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Molecular Endocrinology
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PubMed
volume
29
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PubMed
issue
6
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PubMed
page(s)
801-13
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PubMed
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 September 2017
Mice, the motor system, and human motor neuron pathology
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 September 2017
The role of excitotoxicity in ALS--what is the evidence?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 September 2017
Cannabinoid receptor interactions with the antagonists SR 141716A and SR 144528.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 September 2017
The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 September 2017
Regulation of a neuronal form of focal adhesion kinase by anandamide
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 September 2017
A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 September 2017
Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 September 2017
Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR 141716A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 September 2017
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
31 May 2018
The cannabinoid receptor antagonist SR 141716 prevents acquisition of drinking behavior in alcohol-preferring rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
31 May 2018
Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
31 May 2018
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
31 May 2018
Ligand binding and modulation of cyclic AMP levels depend on the chemical nature of residue 192 of the human cannabinoid receptor 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
31 May 2018
Amyotrophic lateral sclerosis. Insights from genetics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
31 May 2018
Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
31 May 2018
Enzymes for anandamide biosynthesis and metabolism.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
31 May 2018
Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
31 May 2018
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 July 2018
The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Indole-2-carboxamides as allosteric modulators of the cannabinoid CB₁ receptor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Genetic Variations at the Endocannabinoid Type 1 Receptor Gene (CNR1) Are Associated with Obesity Phenotypes in Men
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Cannabinoid receptor type 2 gene is associated with human osteoporosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Cannabinoid mechanism in reinstatement of heroin-seeking after a long period of abstinence in rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Reversal of delta 9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
A cannabinoid mechanism in relapse to cocaine seeking.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in a xenopus oocyte expression system.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447638
retrieved
28 November 2018
Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25866875
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25866875
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Genetics of amyotrophic lateral sclerosis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25866875
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Physical withdrawal in rats tolerant to delta 9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25866875
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The difference between the CB(1) and CB(2) cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB(2)
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25866875
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Endogenous cannabinoids: structure and metabolism
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25866875
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Role of cannabinoid CB2 receptors in glucose homeostasis in rats
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25866875
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25866875
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A Total Synthesis of dl-Δ1-Tetrahydrocannabinol, the Active Constituent of Hashish1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25866875
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25866875
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Knockdown of AMPA receptor GluR2 expression causes delayed neurodegeneration and increases damage by sublethal ischemia in hippocampal CA1 and CA3 neurons
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25866875
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Guidelines in motor neurone disease (MND)/amyotrophic lateral sclerosis (ALS)--from diagnosis to patient care
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Crossref
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https://api.crossref.org/works/10.1210%2FME.2015-1062
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7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of amyotrophic lateral sclerosis--what is the next step?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1210%2FME.2015-1062
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Paracrinicity: the story of 30 years of cellular pituitary crosstalk
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1210%2FME.2015-1062
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1210%2FME.2015-1062
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1210/ME.2015-1062
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2584224
OpenCitations bibliographic resource ID
2584224
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2584224
PMC publication ID
4447638
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2584224
PubMed publication ID
25866875
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2584224
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