(Q30373403)

English

Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation.

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scholarly article

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Europe PubMed Central

PMC publication ID

17 August 2017

Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation. (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

G protein-coupled receptor

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cannabinoid receptor

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1 reference

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Alexandros Makriyannis

9

object named as

Alexandros Makriyannis

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Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Ying Pei

1

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Europe PubMed Central

PMC publication ID

17 August 2017

Richard W Mercier

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Jenine K Anday

3

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Europe PubMed Central

PMC publication ID

17 August 2017

Ganesh A Thakur

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Alexander M Zvonok

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Dow Hurst

6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Patricia H Reggio

7

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Europe PubMed Central

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17 August 2017

David R Janero

8

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Europe PubMed Central

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17 August 2017

publication date

1 November 2008

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Europe PubMed Central

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17 August 2017

Chemistry and Biology

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Europe PubMed Central

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17 August 2017

15

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Europe PubMed Central

PMC publication ID

17 August 2017

11

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Europe PubMed Central

PMC publication ID

17 August 2017

1207-1219

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Europe PubMed Central

PMC publication ID

17 August 2017

Covalent inhibitors of human monoacylglycerol lipase: ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis

1 reference

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Structure of a beta1-adrenergic G-protein-coupled receptor

1 reference

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Crystal structure of the ligand-free G-protein-coupled receptor opsin

1 reference

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20 June 2018

Structural diversity of G protein-coupled receptors and significance for drug discovery

1 reference

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20 June 2018

CB1 cannabinoid antagonists: structure-activity relationships and potential therapeutic applications

1 reference

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20 June 2018

Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor

1 reference

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Pharmacotherapeutic targeting of the endocannabinoid signaling system: drugs for obesity and the metabolic syndrome.

1 reference

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Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands

1 reference

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20 June 2018

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

1 reference

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Computational methods in drug design: modeling G protein-coupled receptor monomers, dimers, and oligomers

1 reference

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20 June 2018

Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R-[125/131I]AM2233.

1 reference

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20 June 2018

F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist

1 reference

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20 June 2018

Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor

1 reference

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20 June 2018

Purification and mass spectroscopic analysis of human CB1 cannabinoid receptor functionally expressed using the baculovirus system

1 reference

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20 June 2018

Targeting the cannabinoid CB2 receptor: mutations, modeling and development of CB2 selective ligands.

1 reference

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20 June 2018

Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Identification of the binding sites of the SR49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors

1 reference

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CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?

1 reference

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20 June 2018

Functional role of serine residues of transmembrane dopamin VII in signal transduction of CB2 cannabinoid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Cannabinergic ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Ligand based structural studies of the CB1 cannabinoid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Enzyme catalysis: removing chemically 'essential' residues by site-directed mutagenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Chemical rescue of phosphoryl transfer in a cavity mutant: a cautionary tale for site-directed mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

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Mutational analysis and molecular modelling of the antagonist SR 144528 binding site on the human cannabinoid CB(2) receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Mutation of a highly conserved aspartate residue in the second transmembrane domain of the cannabinoid receptors, CB1 and CB2, disrupts G-protein coupling

1 reference

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20 June 2018

Ligand binding and modulation of cyclic AMP levels depend on the chemical nature of residue 192 of the human cannabinoid receptor 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression

1 reference

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20 June 2018

Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR 141716A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2.

1 reference

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20 June 2018

Rat brain cannabinoid receptor modulates N-type Ca2+ channels in a neuronal expression system.

1 reference

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Comparative protein modelling by satisfaction of spatial restraints

1 reference

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20 June 2018

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

1 reference

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20 June 2018

Molecular characterization of a peripheral receptor for cannabinoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

The two-state model of receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

Small angle x-ray diffraction studies on the topography of cannabinoids in synaptic plasma membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

5'-Azido-delta 8-THC: a novel photoaffinity label for the cannabinoid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

20 June 2018

(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor

1 reference

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The conformation, location, and dynamic properties of the endocannabinoid ligand anandamide in a membrane bilayer

1 reference

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26 November 2018

Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptor

1 reference

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26 November 2018

SR144528 as inverse agonist of CB2 cannabinoid receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

26 November 2018

Novel, not adenylyl cyclase-coupled cannabinoid binding site in cerebellum of mice

1 reference

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26 November 2018

Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700404

26 November 2018

Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabinoid receptor activation differentially regulates the various adenylyl cyclase isozymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a region of steric interference at the cannabinoid receptor using the active analog approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Construction of a 3D model of the cannabinoid CB1 receptor: determination of helix ends and helix orientation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel electrophilic high affinity irreversible probe for the cannabinoid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-11-Hydroxy-7'-isothiocyanato-1',1'-dimethylheptyl-delta 8-THC: a novel, high-affinity irreversible probe for the cannabinoid receptor in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small angle X-ray diffraction and differential scanning calorimetric studies on O-methyl-(-)-delta 8-tetrahydrocannabinol and its 5' iodinated derivative in membrane bilayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CHEMBIOL.2008.10.011

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

0 references

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