(Q26849265)

language of work or name

1 reference

5 January 2013

1 reference

1 reference

435

1 reference

PubMed

issue

1

1 reference

PubMed

page(s)

102-9

1 reference

Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis

PubMed

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

AT-hook motifs identified in a wide variety of DNA-binding proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Early emergence of raltegravir resistance mutations in patients receiving HAART salvage regimens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Identification of the LEDGF/p75 binding site in HIV-1 integrase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

A role for LEDGF/p75 in targeting HIV DNA integration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

The family of hepatoma-derived growth factor proteins: characterization of a new member HRP-4 and classification of its subfamilies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

LEDGF/p75: a novel nuclear autoantigen at the crossroads of cell survival and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Resistance associated mutations to dolutegravir (S/GSK1349572) in HIV-infected patients--impact of HIV subtypes and prior raltegravir experience.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Retroviral intasome assembly and inhibition of DNA strand transfer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Mechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Screening for antiviral inhibitors of the HIV integrase-LEDGF/p75 interaction using the AlphaScreen luminescent proximity assay

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Identification of old drugs as potential inhibitors of HIV-1 integrase - human LEDGF/p75 interaction via molecular docking

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

An essential role for LEDGF/p75 in HIV integration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of dolutegravir as 10-day monotherapy in HIV-1-infected adults

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Cellular co-factors of HIV-1 integration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Menin critically links MLL proteins with LEDGF on cancer-associated target genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033

Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV Type 1: results of a phase 2, randomized, controlled, dose-ranging clinical trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2012.09.033