(Q27678745)

3

Anita Niedziela-Majka

0 references

Magdeleine Hung

7

Magdeleine Hung

0 references

Roman Sakowicz

16

Roman Sakowicz

0 references

Manuel Tsiang

1

Manuel Tsiang

0 references

Elaine Kan

4

Elaine Kan

0 references

Eric B Lansdon

5

Eric B Lansdon

0 references

Dharmaraj Samuel

8

Dharmaraj Samuel

0 references

Nikolai Y Novikov

9

Nikolai Novikov

0 references

Kerim Babaoglu

13

Kerim Babaoglu

0 references

Romas Geleziunas

15

Romas Geleziunas

0 references

author name string

Gregg S Jones

2

0 references

Wayne Huang

6

0 references

Yili Xu

10

0 references

Michael Mitchell

11

0 references

Hongyan Guo

12

0 references

Xiaohong Liu

Journal of Biological Chemistry

14

0 references

language of work or name

English

0 references

publication date

15 June 2012

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published in

0 references

volume

287

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issue

25

0 references

page(s)

21189-203

0 references

cites work

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Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

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Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

20 March 2017

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LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

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Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain

20 March 2017

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Solution structure of the N-terminal zinc binding domain of HIV-1 integrase

20 March 2017

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HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

20 March 2017

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Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

20 March 2017

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Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

20 March 2017

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FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.

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A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain

29 September 2017

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Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV Type 1: results of a phase 2, randomized, controlled, dose-ranging clinical trial

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Pharmacokinetics and safety of S/GSK1349572, a next-generation HIV integrase inhibitor, in healthy volunteers

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Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex

29 September 2017

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An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule

29 September 2017

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29 September 2017

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29 September 2017

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Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein

29 September 2017

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Screening for antiviral inhibitors of the HIV integrase-LEDGF/p75 interaction using the AlphaScreen luminescent proximity assay

29 September 2017

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Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro

29 September 2017

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Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

29 September 2017

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Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

29 September 2017

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Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

29 September 2017

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A role for LEDGF/p75 in targeting HIV DNA integration

29 September 2017

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Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

29 September 2017

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Homogeneous high-throughput screening assays for HIV-1 integrase 3beta-processing and strand transfer activities

29 September 2017

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Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375541

Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375541

Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375541

Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375541

A novel assay for the DNA strand-transfer reaction of HIV-1 integrase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375541

Characterization of the minimal DNA-binding domain of the HIV integrase protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375541

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375541

A rapid in vitro assay for HIV DNA integration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375541

Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375541

Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375541

In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375541

Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection

2 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347534

Hyrtiosal, from the marine sponge Hyrtios erectus, inhibits HIV-1 integrase binding to viral DNA by a new inhibitor binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347534

Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347534

Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347534

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347534

D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347534

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347534

Peptide inhibitors of HIV-1 integrase dissociate the enzyme oligomers

21 January 2018

1 reference

12 December 2020

Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme

1 reference

12 December 2020

Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance

1 reference

12 December 2020

Anti-infectives: clinical progress of HIV-1 integrase inhibitors

1 reference

12 December 2020