(Q26851658)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24473171%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

14 July 2021

Trabectedin and plitidepsin: drugs from the sea that strike the tumor microenvironment (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24473171%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

20 November 2019

1 reference

ChEBI release 2020-05-28

1 reference

8 February 2021

tetrahydroisoquinolines

1 reference

14 July 2021

1 reference

14 July 2021

1 reference

inferred from abstract

author

Maurizio D'Incalci

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24473171%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

author name string

Paola Allavena

series ordinal

3

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24473171%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Carlos M Galmarini

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24473171%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

language of work or name

1 reference

27 January 2014

8 references

3 April 2019

17 September 2019

13 November 2019

20 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24473171%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

8 February 2021

14 July 2021

8 references

3 April 2019

17 September 2019

13 November 2019

20 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24473171%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

8 February 2021

14 July 2021

12

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24473171%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

issue

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24473171%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

page(s)

719-733

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24473171%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution

6 March 2020

copyright license

6 references

3 April 2019

17 September 2019

13 November 2019

20 November 2019

8 February 2021

14 July 2021

0 references

on focus list of Wikimedia project

ScienceSource

0 references

cites work

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Matrix crosslinking forces tumor progression by enhancing integrin signaling

7 April 2017

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7 April 2017

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7 April 2017

Inflammation and cancer

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7 April 2017

The Hallmarks of Cancer

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Cancer-related inflammation

7 April 2017

1 reference

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Tensional homeostasis and the malignant phenotype

7 April 2017

1 reference

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Myeloid-derived suppressor cells as regulators of the immune system

7 April 2017

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Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells

7 April 2017

1 reference

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Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

7 April 2017

1 reference

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7 April 2017

Fibroblasts in cancer

1 reference

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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

7 April 2017

1 reference

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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

7 April 2017

1 reference

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Alternative activation of macrophages: mechanism and functions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Macrophage diversity enhances tumor progression and metastasis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

The extracellular matrix: not just pretty fibrils

7 April 2017

1 reference

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The role of myeloid cells in the promotion of tumour angiogenesis

7 April 2017

1 reference

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Drug resistance and the solid tumor microenvironment

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Stromal fibroblasts in cancer initiation and progression

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Friends or foes - bipolar effects of the tumour stroma in cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Tumorigenesis and the angiogenic switch

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Tumor-associated macrophages as incessant builders and destroyers of the cancer stroma

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

PPARγ agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Identification and manipulation of tumor associated macrophages in human cancers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Targeting of the innate immunity/inflammation as complementary anti-tumor therapies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Temperature-induced melting of double-stranded DNA in the absence and presence of covalently bonded antitumour drugs: insight from molecular dynamics simulations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Chemokines in cancer related inflammation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Jekyll and Hyde: the role of the microenvironment on the progression of cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

A review of trabectedin (ET-743): a unique mechanism of action.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Tumors as organs: complex tissues that interface with the entire organism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Increased angiogenic sprouting in poor prognosis FL is associated with elevated numbers of CD163+ macrophages within the immediate sprouting microenvironment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

The mechanism of action of plitidepsin.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

A fresh prospect of extracellular matrix hydrolytic enzymes and their substrates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Macrophages define the invasive microenvironment in breast cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Tumour immunity: effector response to tumour and role of the microenvironment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Immune cells as mediators of solid tumor metastasis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Collagen reorganization at the tumor-stromal interface facilitates local invasion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Tumor inflammatory angiogenesis and its chemoprevention

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Monitoring the apoptotic process induced by oxidized low-density lipoprotein in Jurkat T-lymphoblast and U937 monocytic human cell lines

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

The role of ROS and RNS in regulating life and death of blood monocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Opinion: Building epithelial architecture: insights from three-dimensional culture models

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Ecteinascidin-743 inhibits activated but not constitutive transcription.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Tissue structure, nuclear organization, and gene expression in normal and malignant breast

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Transcriptional inhibition of type I collagen gene expression in scleroderma fibroblasts by the antineoplastic drug ecteinascidin 743.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

The multistep nature of cancer development.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

The tumour microenvironment as a target for chemoprevention.

31 May 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD12020719

Molecular Pathways Linking Inflammation and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD12020719

Trabectedin plus pegylated liposomal Doxorubicin in recurrent ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD12020719

XPF-dependent DNA breaks and RNA polymerase II arrest induced by antitumor DNA interstrand crosslinking-mimetic alkaloids.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD12020719

Mode of action of trabectedin in myxoid liposarcomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD12020719

Prognostic significance of macrophage infiltration in leiomyosarcomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD12020719

Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD12020719

Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD12020719

Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD12020719

Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD12020719

The intriguing patterns of tumor response to trabectedin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD12020719

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD12020719

Plitidepsin Cellular Binding and Rac1/JNK Pathway Activation Depend on Membrane Cholesterol Content

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD12020719

Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944511

Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes

28 November 2018

1 reference

12 December 2020

Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma

1 reference

12 December 2020

Tumor associated macrophages in human prostate cancer: relation to clinicopathological variables and survival

1 reference

12 December 2020

The cytotoxic activity of Aplidin in chronic lymphocytic leukemia (CLL) is mediated by a direct effect on leukemic cells and an indirect effect on monocyte-derived cells

1 reference

12 December 2020

Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta

1 reference

12 December 2020

Therapeutic targeting of the tumor microenvironment

1 reference

12 December 2020

Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation

1 reference

12 December 2020

Identifiers

DOI

10.3390/MD12020719

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24473171%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24473171%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

24473171

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24473171%20AND%20SRC:MED&resulttype=core&format=json