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Multiple facets of TPP1 in telomere maintenance
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title
Multiple facets of TPP1 in telomere maintenance
(English)
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PubMed
author name string
Malligarjunan Rajavel
series ordinal
1
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Michael R. Mullins
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2
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Derek J. Taylor
series ordinal
3
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language of work or name
English
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publication date
September 2014
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PubMed
published in
Biochimica et Biophysica Acta
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PubMed
volume
1844
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PubMed
issue
9
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PubMed
page(s)
1550-9
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PubMed
cites work
Human single-stranded DNA binding proteins are essential for maintaining genomic stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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21 March 2017
Finding the end: recruitment of telomerase to telomeres
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
21 March 2017
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
21 March 2017
In vivo stoichiometry of shelterin components
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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21 March 2017
Tpp1/Acd maintains genomic stability through a complex role in telomere protection
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
21 March 2017
Telomere protection by mammalian Pot1 requires interaction with Tpp1
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
21 March 2017
The POT1-TPP1 telomere complex is a telomerase processivity factor
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
21 March 2017
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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21 March 2017
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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21 March 2017
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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21 March 2017
A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2
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PubMed Central
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21 March 2017
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex
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PubMed Central
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21 March 2017
PTOP interacts with POT1 and regulates its localization to telomeres
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PubMed Central
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21 March 2017
The human Rap1 protein complex and modulation of telomere length
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PubMed Central
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21 March 2017
Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1
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PubMed Central
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21 March 2017
Human POT1 facilitates telomere elongation by telomerase
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PubMed Central
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21 March 2017
POT1 as a terminal transducer of TRF1 telomere length control
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PubMed Central
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21 March 2017
Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA
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21 March 2017
Precise binding of single-stranded DNA termini by human RAD52 protein
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21 March 2017
Identification of human Rap1: implications for telomere evolution
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21 March 2017
Control of human telomere length by TRF1 and TRF2
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21 March 2017
TIN2, a new regulator of telomere length in human cells
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21 March 2017
Normal human chromosomes have long G-rich telomeric overhangs at one end
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21 March 2017
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
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21 March 2017
TRF1 is a dimer and bends telomeric DNA
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PubMed Central
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21 March 2017
Single-stranded DNA-binding proteins: multiple domains for multiple functions
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21 March 2017
Structure of the Human Telomeric Stn1-Ten1 Capping Complex
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21 March 2017
Cdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere Maintenance
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21 March 2017
How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA
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21 March 2017
Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres
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Structure of the cell-puncturing device of bacteriophage T4
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21 March 2017
Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA
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21 March 2017
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
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Clustal W and Clustal X version 2.0
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ESPript/ENDscript: Extracting and rendering sequence and 3D information from atomic structures of proteins
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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
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Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression.
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21 March 2017
Pot1, the putative telomere end-binding protein in fission yeast and humans
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21 March 2017
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity
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Functional interaction between telomere protein TPP1 and telomerase
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Telomerase unplugged
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Inside the mammalian telomere interactome: regulation and regulatory activities of telomeres
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Shelterin: the protein complex that shapes and safeguards human telomeres
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Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo
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Loss of hPot1 function leads to telomere instability and a cut-like phenotype
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Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
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Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator
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TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres
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21 March 2017
TIN2 mediates functions of TRF2 at human telomeres
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DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites
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Telomere length regulation
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Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites
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Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
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G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding
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The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection
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28 September 2017
Telomere protection by TPP1/POT1 requires tethering to TIN2
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28 September 2017
Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA.
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28 September 2017
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28 September 2017
Role of shelterin in cancer and aging
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28 September 2017
TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice
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28 September 2017
POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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28 September 2017
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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28 September 2017
Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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28 September 2017
Pot1 and cell cycle progression cooperate in telomere length regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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28 September 2017
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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28 September 2017
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
28 September 2017
Telomere maintenance through spatial control of telomeric proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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28 September 2017
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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28 September 2017
The structure and function of telomerase reverse transcriptase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
28 September 2017
Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
28 September 2017
Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
28 September 2017
Telomere repeat binding factors: keeping the ends in check
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
28 September 2017
OB-fold domains: a snapshot of the evolution of sequence, structure and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
28 September 2017
STRAP: editor for STRuctural Alignments of Proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
28 September 2017
Following G-quartet formation by UV-spectroscopy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
28 September 2017
Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
28 September 2017
Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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28 September 2017
Telomeres: no end in sight
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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28 September 2017
Telomeres: beginning to understand the end.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
28 September 2017
Principle of marginotomy in template synthesis of polynucleotides
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
28 September 2017
Telomere reduction in human colorectal carcinoma and with ageing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
28 September 2017
Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
31 May 2018
Fast 3D motif search of EM density maps using a locally normalized cross-correlation function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
31 May 2018
Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
retrieved
31 May 2018
Telomerase recruitment by the telomere end binding protein-beta facilitates G-quadruplex DNA unfolding in ciliates.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112156
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28 November 2018
Identifiers
DOI
10.1016/J.BBAPAP.2014.04.014
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3442446
OpenCitations bibliographic resource ID
3442446
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3442446
PMC publication ID
4112156
1 reference
stated in
PubMed
PubMed publication ID
24780581
1 reference
stated in
PubMed
ResearchGate publication ID
262000809
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