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Caspase-2 as a tumour suppressor
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PubMed
title
Caspase-2 as a tumour suppressor
(English)
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PubMed
author
Loretta Dorstyn
object named as
L Dorstyn
series ordinal
2
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Sharad Kumar
object named as
S Kumar
series ordinal
3
0 references
author name string
J Puccini
series ordinal
1
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
September 2013
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stated in
PubMed
published in
Cell Death & Differentiation
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stated in
PubMed
volume
20
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stated in
PubMed
issue
9
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stated in
PubMed
page(s)
1133-9
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PubMed
cites work
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
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21 March 2017
Hallmarks of Cancer: The Next Generation
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PubMed Central
reference URL
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retrieved
21 March 2017
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
21 March 2017
Caspase-2 at a glance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
21 March 2017
Identification of a set of genes with developmentally down-regulated expression in the mouse brain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
21 March 2017
The DNA damage response: ten years after
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
21 March 2017
Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
21 March 2017
Role of prodomain in importin-mediated nuclear localization and activation of caspase-2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
21 March 2017
Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
21 March 2017
Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
PIDDosome-independent tumor suppression by Caspase-2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
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28 September 2017
Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
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28 September 2017
Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
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28 September 2017
Causes and consequences of aneuploidy in cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
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28 September 2017
Caspases and cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Characterization of cytoplasmic caspase-2 activation by induced proximity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
A tumor suppressor function for caspase-2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Caspase-2 deficiency enhances aging-related traits in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Caspase function in programmed cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Mitotic catastrophe results in cell death by caspase-dependent and caspase-independent mechanisms.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
The biochemical mechanism of caspase-2 activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
DRONC, an ecdysone-inducible Drosophila caspase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Defects in regulation of apoptosis in caspase-2-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
ICE-like proteases in apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
28 September 2017
PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
31 May 2018
Prodomain-dependent nuclear localization of the caspase-2 (Nedd2) precursor. A novel function for a caspase prodomain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
31 May 2018
Dimerization and autoprocessing of the Nedd2 (caspase-2) precursor requires both the prodomain and the carboxyl-terminal regions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
31 May 2018
Apoptotic cell death and tissue remodelling during mouse mammary gland involution
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741511
retrieved
31 May 2018
Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2013.87
retrieved
21 January 2018
Caspase-2 is required for cell death induced by cytoskeletal disruption
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2013.87
retrieved
21 January 2018
Caspase-8 deficiency facilitates cellular transformation in vitro.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2013.87
retrieved
21 January 2018
Somatic mutations of caspase-2 gene in gastric and colorectal cancers.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FCDD.2013.87
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21 January 2018
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.
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21 January 2018
Mitotic catastrophe: a mechanism for avoiding genomic instability.
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Crossref
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https://api.crossref.org/works/10.1038%2FCDD.2013.87
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21 January 2018
Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23811850
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23811850
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23811850
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Caspase 2 and caspase 3 protein levels as predictors of survival in acute myelogenous leukemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23811850
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Somatic mutation of proapoptotic caspase-2 gene is rare in acute leukemias and common solid cancers
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23811850
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/CDD.2013.87
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Dimensions Publication ID
1026669459
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PMC publication ID
3741511
1 reference
stated in
PubMed
PubMed publication ID
23811850
1 reference
stated in
PubMed
ResearchGate publication ID
243967866
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