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Structures of hepatitis C virus nonstructural proteins required for replicase assembly and function
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scholarly article
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PubMed
title
Structures of hepatitis C virus nonstructural proteins required for replicase assembly and function
(English)
1 reference
stated in
PubMed
main subject
virology
0 references
Hepatitis C virus
1 reference
based on heuristic
inferred from title
hepatitis C
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based on heuristic
inferred from title
author
Charles M. Rice
series ordinal
2
object named as
Charles M Rice
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Crossref
author name string
Meigang Gu
series ordinal
1
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
April 2013
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stated in
PubMed
published in
Current opinion in virology
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stated in
PubMed
volume
3
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stated in
PubMed
issue
2
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stated in
PubMed
page(s)
129-36
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PubMed
cites work
Hepatitis C virus NS5A protein interacts with phosphatidylinositol 4-kinase type IIIalpha and regulates viral propagation
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Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein
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The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors
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Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV
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21 March 2017
Further Insights into the Roles of GTP and the C Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis
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The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor
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Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
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A genome-wide genetic screen for host factors required for hepatitis C virus propagation
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An Amphipathic -Helix at the C Terminus of Hepatitis C Virus Nonstructural Protein 4B Mediates Membrane Association
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21 March 2017
Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B
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21 March 2017
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
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21 March 2017
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex
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21 March 2017
Hepatitis C Viral NS3-4A Protease Activity Is Enhanced by the NS3 Helicase
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21 March 2017
Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly
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21 March 2017
The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication
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21 March 2017
Hepatitis C Virus p7 and NS2 Proteins Are Essential for Production of Infectious Virus
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21 March 2017
Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase
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21 March 2017
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
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21 March 2017
Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation
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21 March 2017
Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture
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PubMed Central
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21 March 2017
Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides
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PubMed Central
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21 March 2017
Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase
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PubMed Central
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21 March 2017
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
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PubMed Central
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21 March 2017
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide
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21 March 2017
Replication of hepatitis C virus
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PubMed Central
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21 March 2017
Efficient initiation of HCV RNA replication in cell culture
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PubMed Central
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21 March 2017
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
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PubMed Central
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21 March 2017
Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA
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PubMed Central
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21 March 2017
Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
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7 April 2017
A hepatitis C virus NS5A phosphorylation site that regulates RNA replication
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PubMed Central
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28 September 2017
Hepatitis C RNA-dependent RNA polymerase inhibitors: a review of structure-activity and resistance relationships; different scaffolds and mutations.
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28 September 2017
Turning hepatitis C into a real virus
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PubMed Central
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28 September 2017
NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes
1 reference
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PubMed Central
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28 September 2017
Conserved GXXXG- and S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replication
1 reference
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PubMed Central
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28 September 2017
Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A.
1 reference
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PubMed Central
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28 September 2017
Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus
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28 September 2017
New opportunities in anti-hepatitis C virus drug discovery: targeting NS4B.
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28 September 2017
Organelle-like membrane compartmentalization of positive-strand RNA virus replication factories
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28 September 2017
Hepatitis C virus RNA replication requires a conserved structural motif within the transmembrane domain of the NS5B RNA-dependent RNA polymerase
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PubMed Central
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28 September 2017
Identification of a novel phosphorylation site in hepatitis C virus NS5A
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PubMed Central
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28 September 2017
All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding
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PubMed Central
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28 September 2017
Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target
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28 September 2017
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
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28 September 2017
Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory
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28 September 2017
Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles.
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28 September 2017
RNA-dependent RNA polymerases from Flaviviridae
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28 September 2017
Biochemical characterization of recombinant hepatitis C virus nonstructural protein 4B: evidence for ATP/GTP hydrolysis and adenylate kinase activity.
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28 September 2017
Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis
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28 September 2017
NS5A--from obscurity to new target for HCV therapy
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28 September 2017
Host factors involved in the replication of hepatitis C virus
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PubMed Central
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28 September 2017
Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication?
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PubMed Central
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28 September 2017
Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication
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PubMed Central
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28 September 2017
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors
1 reference
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PubMed Central
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28 September 2017
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856683
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28 September 2017
De novo initiation pocket mutations have multiple effects on hepatitis C virus RNA-dependent RNA polymerase activities
1 reference
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PubMed Central
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28 September 2017
A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856683
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28 September 2017
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.
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PubMed Central
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28 September 2017
The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo
1 reference
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PubMed Central
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28 September 2017
Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon
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PubMed Central
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28 September 2017
The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently
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PubMed Central
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28 September 2017
Single-base pair unwinding and asynchronous RNA release by the hepatitis C virus NS3 helicase
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PubMed Central
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31 May 2018
The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly
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31 May 2018
Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicase
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31 May 2018
Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner
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PubMed Central
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28 November 2018
The domain 2 of the HCV NS5A protein is intrinsically unstructured
1 reference
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PubMed Central
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28 November 2018
Domain 3 of non-structural protein 5A from hepatitis C virus is natively unfolded
1 reference
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PubMed Central
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28 November 2018
The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856683
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28 November 2018
Domain 2 of nonstructural protein 5A (NS5A) of hepatitis C virus is natively unfolded.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856683
retrieved
28 November 2018
Identifiers
DOI
10.1016/J.COVIRO.2013.03.013
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
450756
OpenCitations bibliographic resource ID
450756
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
450756
PMC publication ID
3856683
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
450756
PubMed publication ID
23601958
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
450756
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