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Molecular pathways: targeting phosphoinositide 3-kinase p110-delta in chronic lymphocytic leukemia
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scholarly article
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PubMed
title
Molecular pathways: targeting phosphoinositide 3-kinase p110-delta in chronic lymphocytic leukemia
(English)
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main subject
lymphocyte
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leukemia
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based on heuristic
inferred from title
chronic lymphocytic leukemia
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based on heuristic
inferred from title
author name string
S. E. M. Herman
series ordinal
1
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Crossref
A. J. Johnson
series ordinal
2
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Crossref
language of work or name
English
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PubMed
publication date
1 August 2012
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stated in
PubMed
published in
Clinical Cancer Research
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stated in
PubMed
volume
18
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PubMed
issue
15
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stated in
PubMed
page(s)
4013-8
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PubMed
cites work
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The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival
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p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
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PubMed Central
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21 March 2017
PI3K in lymphocyte development, differentiation and activation
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21 March 2017
The role of PI3K in immune cells
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21 March 2017
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation
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Phosphoinositide 3-kinase: diverse roles in immune cell activation
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PubMed Central
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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
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7 April 2017
The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
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PubMed Central
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28 September 2017
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
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PubMed Central
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28 September 2017
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
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PubMed Central
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Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages
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Regulation of class IA PI3Ks: is there a role for monomeric PI3K subunits?
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Signalling through Class I PI3Ks in mammalian cells
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Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
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Towards an understanding of isoform specificity in phosphoinositide 3-kinase signalling in lymphocytes
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28 September 2017
Targeting the PI3K-Akt pathway in human cancer: rationale and promise
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28 September 2017
Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells
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PubMed Central
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28 September 2017
Phosphoinositide 3-kinase signalling--which way to target?
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stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425377
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28 September 2017
PI3K-signalling in B- and T-cells: insights from gene-targeted mice
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Regulation of B-cell fate by antigen-receptor signals
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28 September 2017
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425377
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28 September 2017
Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.
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PubMed Central
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28 September 2017
Ten years of protein kinase B signalling: a hard Akt to follow
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28 September 2017
Phosphoinositide 3-kinase signalling pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425377
retrieved
28 September 2017
Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase Cgamma pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425377
retrieved
28 September 2017
Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425377
retrieved
28 November 2018
Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425377
retrieved
28 November 2018
B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22711705
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Why do phosphatidylinositol kinases have so many isoforms?
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22711705
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
[Detection of soluble Apo-1/Fas in plasma, pleural and ascites fluid of malignant tumor patients and its clinical significance]
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22711705
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1158/1078-0432.CCR-11-1402
1 reference
stated in
PubMed
PMC publication ID
3425377
1 reference
stated in
PubMed
PubMed publication ID
22711705
1 reference
stated in
PubMed
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