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Developing treatment for spinal and bulbar muscular atrophy
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scholarly article
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PubMed
title
Developing treatment for spinal and bulbar muscular atrophy
(English)
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main subject
muscular atrophy
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based on heuristic
inferred from title
author name string
Kenneth H. Fischbeck
series ordinal
1
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Crossref
language of work or name
English
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stated in
PubMed
publication date
December 2012
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stated in
PubMed
published in
Progress in Neurobiology
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stated in
PubMed
volume
99
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PubMed
issue
3
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PubMed
page(s)
257-61
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PubMed
cites work
Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor
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PubMed Central
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21 March 2017
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
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PubMed Central
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21 March 2017
Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA).
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 September 2017
Neurotoxic effects of androgens in spinal and bulbar muscular atrophy.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 September 2017
Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 September 2017
Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 September 2017
Therapeutic approaches to spinal and bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 September 2017
Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 September 2017
B2 attenuates polyglutamine-expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 September 2017
Clinical features of spinal and bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 September 2017
Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 September 2017
Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 September 2017
Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 September 2017
Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 September 2017
Mitochondrial abnormalities in spinal and bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 September 2017
ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 September 2017
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 September 2017
17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 September 2017
Histone deacetylase inhibitors reduce polyglutamine toxicity
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 September 2017
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 September 2017
CREB-binding protein sequestration by expanded polyglutamine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 September 2017
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 September 2017
Standard and modified statistical MUNE evaluations in spinal-bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
31 May 2018
Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 November 2018
Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 November 2018
Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
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28 November 2018
Androgen 5-alpha-reductase type 2 is highly expressed and active in rat spinal cord motor neurones
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 November 2018
Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 November 2018
Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 November 2018
Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 November 2018
Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460036
retrieved
28 November 2018
SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22668795
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Altered acetylation in polyglutamine disease: an opportunity for therapeutic intervention?
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22668795
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Expression of X-linked bulbospinal muscular atrophy (Kennedy disease) in two homozygous women
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22668795
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.PNEUROBIO.2012.05.012
0 references
PMC publication ID
3460036
1 reference
stated in
PubMed
PubMed publication ID
22668795
1 reference
stated in
PubMed
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