(Q27010429)

M. Brancaccio

series ordinal

2

1 reference

language of work or name

1 reference

1 June 2014

1 reference

published in

Cardiovascular Research

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volume

102

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issue

3

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page(s)

346-61

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Proteotoxicity and cardiac dysfunction--Alzheimer's disease of the heart?

cites work

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Molecular chaperones in protein folding and proteostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Heat shock protein 90 transfection reduces ischemia-reperfusion-induced myocardial dysfunction via reciprocal endothelial NO synthase serine 1177 phosphorylation and threonine 495 dephosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Biology of cardiac arrhythmias: ion channel protein trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Role of priming stresses and Hsp70 in protection from ischemia-reperfusion injury in cardiac and skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Gene transfer of heat-shock protein 70 reduces infarct size in vivo after ischemia/reperfusion in the rabbit heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

CHIP, a cochaperone/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Chaperone-assisted selective autophagy is essential for muscle maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

BAG3 deficiency results in fulminant myopathy and early lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Common variants in HSPB7 and FRMD4B associated with advanced heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Genetic association study identifies HSPB7 as a risk gene for idiopathic dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Mutation in BAG3 causes severe dominant childhood muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Inheritance patterns and phenotypic features of myofibrillar myopathy associated with a BAG3 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Induction of heat shock response protects the heart against atrial fibrillation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Increased expression of HSP27 protects canine myocytes from simulated ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Roles for αB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Transgene overexpression of alphaB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Alpha B-crystallin suppresses pressure overload cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Alpha B-crystallin mutation in dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

The emerging role of HSP20 as a multifunctional protective agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

H11 kinase prevents myocardial infarction by preemptive preconditioning of the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Activation of the bone morphogenetic protein receptor by H11kinase/Hsp22 promotes cardiac cell growth and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

H11 kinase/heat shock protein 22 deletion impairs both nuclear and mitochondrial functions of STAT3 and accelerates the transition into heart failure on cardiac overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

H11 kinase is a novel mediator of myocardial hypertrophy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Melusin gene (ITGB1BP2) nucleotide variations study in hypertensive and cardiopathic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Identification of a missense mutation in the melusin-encoding ITGB1BP2 gene in a patient with dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Ablation of C/EBP homologous protein attenuates endoplasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

ATF6 is important under both pathological and physiological states in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

A thrombospondin-dependent pathway for a protective ER stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

21 January 2018

What is a co-chaperone?

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Hsp90: a specialized but essential protein-folding tool

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

The small heat shock proteins family: the long forgotten chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

HSPBs: small proteins with big implications in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Small heat shock proteins, protein degradation and protein aggregation diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Biology of endoplasmic reticulum stress in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

New concepts of endoplasmic reticulum function in the heart: programmed to conserve

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Two close, too close: sarcoplasmic reticulum-mitochondrial crosstalk and cardiomyocyte fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

CHIP: a link between the chaperone and proteasome systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Build it up-Tear it down: protein quality control in the cardiac sarcomere

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Guidelines for the use and interpretation of assays for monitoring autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Cardiovascular autophagy: concepts, controversies, and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Chaperones in cell cycle regulation and mitogenic signal transduction: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Heat-shock protein hsp90 governs the activity of pp60v-src kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Morgana and melusin: two fairies chaperoning signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Between genotype and phenotype: protein chaperones and evolvability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Understanding of the Hsp90 molecular chaperone reaches new heights.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Chaperonin overexpression promotes genetic variation and enzyme evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

The therapeutic potential of ischemic conditioning: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Stressful preconditioning and HSP70 overexpression attenuate proteotoxicity of cellular ATP depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Blocking the endogenous increase in HSP 72 increases susceptibility to hypoxia and reoxygenation in isolated adult feline cardiocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Guidelines for the nomenclature of the human heat shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Association of the chaperone alphaB-crystallin with titin in heart muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Converging concepts of protein folding in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Desmin mutation responsible for idiopathic dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Desmin myopathy, a skeletal myopathy with cardiomyopathy caused by mutations in the desmin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Importance of small heat shock protein 20 (hsp20) C-terminal extension in cardioprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

BAG3: a multifaceted protein that regulates major cell pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

The stress-inducible HspB8-Bag3 complex induces the eIF2alpha kinase pathway: implications for protein quality control and viral factory degradation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Matricellular proteins in cardiac adaptation and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Pathophysiology and prevention of atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

New ideas about atrial fibrillation 50 years on.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Molecular mechanisms of remodeling in human atrial fibrillation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

New antiarrhythmic drugs for treatment of atrial fibrillation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Heat shock proteins as molecular targets for intervention in atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

HSF transcription factor family, heat shock response, and protein intrinsic disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Exercise and cardioprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Heat shock proteins: therapeutic drug targets for chronic neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Small-molecule proteostasis regulators for protein conformational diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Celastrols as inducers of the heat shock response and cytoprotection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Mechanism of simvastatin on induction of heat shock protein in osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

HSF1 and constitutively active HSF1 improve vascular endothelial function (heat shock proteins improve vascular endothelial function).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Statins modulate heat shock protein expression and enhance retinal ganglion cell survival after transient retinal ischemia/reperfusion in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Single oral dose of geranylgeranylacetone induces heat-shock protein 72 and renders protection against ischemia/reperfusion injury in rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

The role of coenzyme Q10 in statin-associated myopathy: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Phosphorylation of alphaB-crystallin in mitotic cells and identification of enzymatic activities responsible for phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

A short lived protein involved in the heat shock sensing mechanism responsible for stress-activated protein kinase 2 (SAPK2/p38) activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Heat shock protein 27 is a substrate of cGMP-dependent protein kinase in intact human platelets: phosphorylation-induced actin polymerization caused by HSP27 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Phosphorylation by cyclic AMP-dependent protein kinase inhibits chaperone-like activity of human HSP22 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Small heat shock proteins HSP27 and alphaB-crystallin: cytoprotective and oncogenic functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVU049