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Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers
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scholarly article
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stated in
PubMed
title
Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers
(English)
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main subject
autophagy
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author
Eileen White
object named as
E. White
series ordinal
2
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author name string
A. M. Strohecker
series ordinal
1
1 reference
stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
July 2014
1 reference
stated in
PubMed
published in
Cancer Discovery
1 reference
stated in
PubMed
volume
4
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stated in
PubMed
issue
7
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stated in
PubMed
page(s)
766-72
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stated in
PubMed
cites work
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PubMed Central
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BRAF mutations in hairy-cell leukemia
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PubMed Central
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Autophagy suppresses tumorigenesis through elimination of p62
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21 March 2017
Autophagy mediates the mitotic senescence transition
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21 March 2017
Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction
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21 March 2017
Mechanisms of mitophagy
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PubMed Central
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21 March 2017
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21 March 2017
Mutations of the BRAF gene in human cancer
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PubMed Central
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21 March 2017
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
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21 March 2017
Loss of autophagy in the central nervous system causes neurodegeneration in mice
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21 March 2017
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21 March 2017
BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas
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Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
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Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF
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21 March 2017
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The role of autophagy during the early neonatal starvation period
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7 April 2017
Mitochondria and cancer
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7 April 2017
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7 April 2017
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
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7 April 2017
Pancreatic cancers require autophagy for tumor growth
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7 April 2017
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7 April 2017
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
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7 April 2017
Role of autophagy in cancer
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7 April 2017
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
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7 April 2017
On respiratory impairment in cancer cells
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7 April 2017
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation
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7 April 2017
A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme
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Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma
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28 September 2017
Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors
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28 September 2017
Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma
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28 September 2017
Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.
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28 September 2017
Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion
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28 September 2017
Hallmarks of a new era in mitochondrial biochemistry
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28 September 2017
p53 status determines the role of autophagy in pancreatic tumour development
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090279
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28 September 2017
Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090279
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28 September 2017
Tumor adaptation and resistance to RAF inhibitors
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PubMed Central
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28 September 2017
Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma
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PubMed Central
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28 September 2017
Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma
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28 September 2017
Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090279
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28 September 2017
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
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28 September 2017
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.
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28 September 2017
Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.
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28 September 2017
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF.
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28 September 2017
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.
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28 September 2017
Relevance of mitochondrial genetics and metabolism in cancer development
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28 September 2017
Selective autophagy in budding yeast
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28 September 2017
Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency
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28 September 2017
Deconvoluting the context-dependent role for autophagy in cancer
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28 September 2017
Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression.
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28 September 2017
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
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28 September 2017
Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome
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PubMed Central
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28 September 2017
Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
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28 September 2017
Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent
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28 September 2017
Spatial coupling of mTOR and autophagy augments secretory phenotypes.
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PubMed Central
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28 September 2017
BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications
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PubMed Central
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28 September 2017
Principles and current strategies for targeting autophagy for cancer treatment
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PubMed Central
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28 September 2017
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090279
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28 September 2017
Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090279
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28 September 2017
Learning from oncocytic tumors: Why choose inefficient mitochondria?
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PubMed Central
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28 September 2017
Glutamine addiction: a new therapeutic target in cancer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090279
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28 September 2017
Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation
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PubMed Central
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28 September 2017
Role of autophagy in suppression of inflammation and cancer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090279
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28 September 2017
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090279
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28 September 2017
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
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PubMed Central
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28 September 2017
High frequency of BRAF mutations in nevi
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28 September 2017
Ammonia derived from glutaminolysis is a diffusible regulator of autophagy
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31 May 2018
Diminished tumorigenic phenotype after depletion of mitochondrial DNA.
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31 May 2018
Tumor-forming ability in athymic nude mice of human cell lines devoid of mitochondrial DNA.
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31 May 2018
A dual role for autophagy in a murine model of lung cancer
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28 November 2018
Towards a unified model of RAF inhibitor resistance
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28 November 2018
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
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28 November 2018
Autophagy is required to maintain muscle mass.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090279
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28 November 2018
Autophagy is essential for preimplantation development of mouse embryos.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090279
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28 November 2018
Identifiers
DOI
10.1158/2159-8290.CD-14-0196
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3485680
OpenCitations bibliographic resource ID
3485680
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3485680
PMC publication ID
4090279
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3485680
PubMed publication ID
24860158
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3485680
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