(Q27300308)

26 June 2017

title

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs (English)

1 reference

26 June 2017

Carlota Oleaga

1

1 reference

ORCID Public Data File 2021

James J Hickman

23

object named as

James J Hickman

1 reference

26 June 2017

Catia Bernabini

2

1 reference

26 June 2017

Alec S T Smith

3

1 reference

26 June 2017

Balaji Srinivasan

4

1 reference

26 June 2017

Max Jackson

5

1 reference

26 June 2017

William McLamb

6

1 reference

26 June 2017

Vivien Platt

7

1 reference

26 June 2017

Richard Bridges

8

1 reference

26 June 2017

Yunqing Cai

9

1 reference

26 June 2017

Navaneetha Santhanam

10

1 reference

26 June 2017

Bonnie Berry

11

1 reference

26 June 2017

Sarah Najjar

12

1 reference

26 June 2017

Nesar Akanda

13

1 reference

26 June 2017

Xiufang Guo

14

1 reference

26 June 2017

Candace Martin

15

1 reference

26 June 2017

Gail Ekman

16

1 reference

26 June 2017

Mandy B Esch

17

1 reference

26 June 2017

Jessica Langer

18

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26 June 2017

Gladys Ouedraogo

19

1 reference

26 June 2017

Jose Cotovio

20

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26 June 2017

Lionel Breton

21

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26 June 2017

Michael L Shuler

22

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26 June 2017

language of work or name

English

0 references

publication date

3 February 2016

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26 June 2017

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26 June 2017

volume

6

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26 June 2017

page(s)

20030

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Creative Commons Attribution 4.0 International

26 June 2017

copyright license

start time

3 February 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

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Molecular and therapeutic potential and toxicity of valproic acid

21 March 2017

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Bridging Functional and Structural Cardiotoxicity Assays Using Human Embryonic Stem Cell-Derived Cardiomyocytes for a More Comprehensive Risk Assessment

21 March 2017

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Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

28 September 2017

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An evaluation of hepatotoxicity in breast cancer patients receiving injection Doxorubicin

28 September 2017

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In vitro Differentiation of Functional Human Skeletal Myotubes in a Defined System

28 September 2017

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How multi-organ microdevices can help foster drug development

28 September 2017

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Clinical development success rates for investigational drugs

28 September 2017

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Accurate prediction of drug-induced liver injury using stem cell-derived populations

28 September 2017

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Valproic acid protects motor neuron death by inhibiting oxidative stress and endoplasmic reticulum stress-mediated cytochrome C release after spinal cord injury

28 September 2017

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Long-term maintenance of HepaRG cells in serum-free conditions and application in a repeated dose study.

28 September 2017

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Correlation of embryonic skeletal muscle myotube physical characteristics with contractile force generation on an atomic force microscope-based bio-microelectromechanical systems device

28 September 2017

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Synergistically killing activity of aspirin and histone deacetylase inhibitor valproic acid (VPA) on hepatocellular cancer cells

28 September 2017

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A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

28 September 2017

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Microengineered physiological biomimicry: organs-on-chips.

28 September 2017

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Glucose and fatty acid metabolism in a 3 tissue in-vitro model challenged with normo- and hyperglycaemia

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Pharmacological actions of statins: a critical appraisal in the management of cancer

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Acetaminophen: beyond pain and Fever-relieving

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system

28 September 2017

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Inhibition of neuronal cholesterol biosynthesis with lovastatin leads to impaired synaptic vesicle release even in the presence of lipoproteins or geranylgeraniol

28 September 2017

1 reference

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Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Atorvastatin-induced acute elevation of hepatic enzymes and the absence of cross-toxicity of pravastatin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Statins and neuroprotection: a prescription to move the field forward

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Addition of glutamate to serum-free culture promotes recovery of electrical activity in adult hippocampal neurons in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Optimization of chemically defined cell culture media--replacing fetal bovine serum in mammalian in vitro methods.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Characterization of a human fetal spinal cord stem cell line, NSI-566RSC, and its induction to functional motoneurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Doxorubicin: the good, the bad and the ugly effect

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Statin induced myotoxicity: the lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Three-dimensional cellular microarray for high-throughput toxicology assays

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Atorvastatin associated liver disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Adverse drug event surveillance and drug withdrawals in the United States, 1969-2002: the importance of reporting suspected reactions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Liver function test abnormalities and pruritus in a patient treated with atorvastatin: case report and review of the literature

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Acetaminophen poisoning and toxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Tissue-engineered human bioartificial muscles expressing a foreign recombinant protein for gene therapy

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Comparative cytotoxic effects of acetaminophen (N-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytes.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Target organ profiles in toxicity studies supporting human dosing: an assessment of recovery and chronic dosing.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Rhabdomyolysis in an elderly multitreated patient: multiple drug interactions after statin withdrawal.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

A new twist to an old tale: novel insights into the differential toxicities of acetaminophen and its regioisomer N-acetyl-meta-aminophenol (AMAP).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

The Comparison between Conditioned Media and Serum-Free Media in Human Embryonic Stem Cell Culture and Differentiation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Study of plasma level of atorvastatin and its effect on lipid profile.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Direct effects of doxorubicin on skeletal muscle contribute to fatigue.

28 November 2018

1 reference

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Connected culture of murine hepatocytes and HUVEC in a multicompartmental bioreactor.

28 November 2018

1 reference

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Toxicity of valproic acid in mice with decreased plasma and tissue carnitine stores

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Acetaminophen-mediated cardioprotection via inhibition of the mitochondrial permeability transition pore-induced apoptotic pathway.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Pharmacokinetics of atorvastatin and its metabolites after single and multiple dosing in hypercholesterolaemic haemodialysis patients

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Plasma concentrations after high-dose (45 mg.kg-1) rectal acetaminophen in children.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4738272

Evaluation of a novel in vitro Caco-2 hepatocyte hybrid system for predicting in vivo oral bioavailability

28 November 2018

1 reference

12 December 2020

Doxorubicin and doxorubicinol pharmacokinetics and tissue concentrations following bolus injection and continuous infusion of doxorubicin in the rabbit

1 reference

12 December 2020

Inhibition of histone deacetylase on ventricular remodeling in infarcted rats

1 reference

12 December 2020

Protective role of atorvastatin against doxorubicin-induced cardiotoxicity and testicular toxicity in mice

1 reference

12 December 2020

Neuronal nitric oxide synthase protects neuroblastoma cells from oxidative stress mediated by garlic derivatives

1 reference

12 December 2020

A Comparative Study of Mouse Liver Proteins Arylated by Reactive Metabolites of Acetaminophen and Its Nonhepatotoxic Regioisomer, 3'-Hydroxyacetanilide

1 reference

12 December 2020

Identifiers

DOI

10.1038/SREP20030

1 reference

Dimensions Publication ID

26 June 2017

1034383259

0 references

OpenCitations bibliographic resource ID

3433650

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3433650

PMC publication ID

4738272

0 references

1 reference