(Q27303843)

26 June 2017

title

Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment (English)

1 reference

26 June 2017

0 references

Minghai Zhou

1

1 reference

26 June 2017

Gregory Ottenberg

2

1 reference

26 June 2017

Gian Franco Sferrazza

3

1 reference

26 June 2017

Christopher Hubbs

4

1 reference

26 June 2017

Mohammad Fallahi

5

1 reference

26 June 2017

Gavin Rumbaugh

6

1 reference

26 June 2017

Alicia F Brantley

7

1 reference

26 June 2017

Corinne I Lasmézas

8

1 reference

26 June 2017

language of work or name

English

0 references

publication date

11 February 2015

1 reference

26 June 2017

1 reference

26 June 2017

volume

138

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26 June 2017

issue

Pt 4

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26 June 2017

page(s)

992-1008

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The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein

26 June 2017

cites work

1 reference

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Sustained translational repression by eIF2α-P mediates prion neurodegeneration

21 March 2017

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21 March 2017

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Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

21 March 2017

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21 March 2017

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Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy

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A specific amyloid-beta protein assembly in the brain impairs memory

21 March 2017

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21 March 2017

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

7 April 2017

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Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1

7 April 2017

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

7 April 2017

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NAD⁺-dependent enzymes at the endoplasmic reticulum

7 April 2017

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Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts

28 September 2017

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Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation.

28 September 2017

1 reference

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A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity

28 September 2017

1 reference

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Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?

28 September 2017

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Biomarker evidence for uncoupling of amyloid build-up and toxicity in Alzheimer's disease

28 September 2017

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Autophagy and neuronal cell death in neurological disorders

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Sporadic human prion diseases: molecular insights and diagnosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Classic and new animal models of Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Huntington disease and the huntingtin protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Aβ toxicity in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Intercellular (mis)communication in neurodegenerative disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Complex roles of members of the ADP-ribosyl transferase super family in immune defences: looking beyond PARP1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Lysosomal acidification mechanisms

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Highly neurotoxic monomeric α-helical prion protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Control of autophagy as a therapy for neurodegenerative disease

28 September 2017

1 reference

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Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Genetic mouse models of neurodegenerative diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

In vivo demonstration that alpha-synuclein oligomers are toxic

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

The Parkinson disease protein α-synuclein inhibits autophagy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

NAD+ depletion or PAR polymer formation: which plays the role of executioner in ischaemic cell death?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

The intricate mechanisms of neurodegeneration in prion diseases.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

The transcellular spread of cytosolic amyloids, prions, and prionoids

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Autophagy, prion infection and their mutual interactions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

NAD depletion by FK866 induces autophagy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Disease-associated prion protein oligomers inhibit the 26S proteasome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Autophagy and neurodegeneration: when the cleaning crew goes on strike

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Accumulation of prion protein in the brain that is not associated with transmissible disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

The role of poly(ADP-ribose) polymerase-1 in CNS disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Astrocytes in transmissible spongiform encephalopathies (prion diseases).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Physiological relevance of the endogenous mono(ADP-ribosyl)ation of cellular proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Mediation of cell death by poly(ADP-ribose) polymerase-1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Nasal drug administration: potential for targeted central nervous system delivery

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Pathogenesis of prion diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

The role of Ca2+ in the regulation of intramitochondrial energy production in heart.

28 September 2017

1 reference

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Neuronal apoptosis in fatal familial insomnia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Parenteral application of NADH in Parkinson's disease: clinical improvement partially due to stimulation of endogenous levodopa biosynthesis.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

The clinical benefit of NADH as stimulator of endogenous L-dopa biosynthesis in parkinsonian patients

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840455

Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death

31 May 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV002

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV002

Kainate-mediated excitotoxicity induces neuronal death in the rat spinal cord in vitro via a PARP-1 dependent cell death pathway (Parthanatos).

21 January 2018

1 reference

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Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathy

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV002

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV002

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV002

Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV002

Excitotoxicity through NMDA receptors mediates cerebellar granule neuron apoptosis induced by prion protein 90-231 fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV002

Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV002

Treatment of Alzheimer's disease with stabilized oral nicotinamide adenine dinucleotide: a randomized, double-blind study.

21 January 2018

1 reference

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Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein

28 November 2018

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12 December 2020

Pharmacological Effects of Exogenous NAD on Mitochondrial Bioenergetics, DNA Repair, and Apoptosis

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12 December 2020

Modulation of cytochrome c-mediated extramitochondrial NADH oxidation by contact site density

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12 December 2020

Neuronal autophagic vacuoles in experimental scrapie and Creutzfeldt-Jakob disease

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12 December 2020

Repression of phosphoenolpyruvate carboxykinase gene activity by insulin is blocked by 3-aminobenzamide but not by PD128763, a selective inhibitor of poly(ADP-ribose) polymerase

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12 December 2020

Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease

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12 December 2020

Identifiers

DOI

10.1093/BRAIN/AWV002

1 reference

26 June 2017

0 references

1 reference