(Q35103426)

6 August 2017

title

NAD+ depletion or PAR polymer formation: which plays the role of executioner in ischaemic cell death? (English)

1 reference

6 August 2017

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C Siegel

1

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6 August 2017

L D McCullough

series ordinal

2

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6 August 2017

language of work or name

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19 January 2011

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6 August 2017

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6 August 2017

volume

203

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6 August 2017

issue

1

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6 August 2017

page(s)

225-234

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Sex differences in cerebral ischemia: possible molecular mechanisms

6 August 2017

cites work

1 reference

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NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death

9 July 2018

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Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis.

9 July 2018

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Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion

9 July 2018

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Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway

9 July 2018

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Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons

9 July 2018

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Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke

9 July 2018

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Sex differences in caspase activation after stroke

9 July 2018

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Cellular and molecular neurobiology of brain preconditioning

9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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Pathways to ischemic neuronal cell death: are sex differences relevant?

9 July 2018

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Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease

9 July 2018

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Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging.

9 July 2018

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9 July 2018

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Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases.

9 July 2018

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Minocycline treatment in acute stroke: an open-label, evaluator-blinded study.

9 July 2018

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SIRT1 transgenic mice show phenotypes resembling calorie restriction

9 July 2018

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Sirtuins: critical regulators at the crossroads between cancer and aging

9 July 2018

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Hypoglycemia, brain energetics, and hypoglycemic neuronal death

9 July 2018

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SIRT1 and neuronal diseases

9 July 2018

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NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity

9 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Poly(ADP-ribose) (PAR) polymer is a death signal

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Nicotinamide reduces hypoxic ischemic brain injury in the newborn rat

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Paradox of Ca2+ signaling, cell death and stroke

9 July 2018

1 reference

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The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated "anti-apoptotic" pathways

9 July 2018

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Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors

9 July 2018

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Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection

9 July 2018

1 reference

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Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

9 July 2018

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Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Enzymology of NAD+ homeostasis in man.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Nicotinamide attenuates focal ischemic brain injury in rats: with special reference to changes in nicotinamide and NAD+ levels in ischemic core and penumbra

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Feeding active neurons: (re)emergence of a nursing role for astrocytes

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

The harlequin mouse mutation downregulates apoptosis-inducing factor

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Caspases as treatment targets in stroke and neurodegenerative diseases

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Molecular characterization of mitochondrial apoptosis-inducing factor

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Reactions between nitric oxide, superoxide, and peroxynitrite: footprints of peroxynitrite in vivo

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Metabolic coupling between glia and neurons.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Neurotransmitters regulate energy metabolism in astrocytes: implications for the metabolic trafficking between neural cells.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition

9 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

Energy-efficient action potentials in hippocampal mossy fibers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

Nicotinamide Offers Multiple Protective Mechanisms in Stroke as a Precursor for NAD<sup>+</sup>, as a PARP Inhibitor and by Partial Restoration of Mitochondrial Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

Postischemic treatment of neonatal cerebral ischemia should target autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

Specific caspase inhibitor Q-VD-OPh prevents neonatal stroke in P7 rat: a role for gender.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

NAD+ as a metabolic link between DNA damage and cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

NADH can enter into astrocytes and block poly(ADP-ribose) polymerase-1-mediated astrocyte death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1748-1716.2010.02229.X

Resveratrol mimics ischemic preconditioning in the brain

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135708

Sex differences in stroke

27 September 2018

1 reference

12 December 2020

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1 reference

12 December 2020

The NOS inhibitor, 7-nitroindazole, decreases focal infarct volume but not the response to topical acetylcholine in pial vessels

1 reference

12 December 2020

Neuronal death in brain infarcts in man

1 reference

12 December 2020

Neither energy collapse nor transcription underlie in vitro neurotoxicity of poly(ADP-ribose) polymerase hyper-activation

1 reference

12 December 2020

10.1111/J.1748-1716.2010.02229.X

Identifiers

DOI

1 reference

6 August 2017

1 reference

6 August 2017

1 reference