(Q27306784)

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Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma

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Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma (English)

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Michael P. Murphy

object named as

Michael P Murphy

14

author given names

Michael P

author last names

Murphy

1 reference

PubMed publication ID

19 October 2023

Nicholas H. Heintz

16

object named as

Nicholas H Heintz

author given names

Nicholas H

author last names

Heintz

1 reference

PubMed publication ID

19 October 2023

1

object named as

Brian Cunniff

author given names

Brian

author last names

Cunniff

1 reference

PubMed publication ID

19 October 2023

8

object named as

Kelly Butnor

author given names

Kelly

author last names

Butnor

1 reference

PubMed publication ID

19 October 2023

author name string

Kheng Newick

2

author given names

Kheng

author last names

Newick

1 reference

PubMed publication ID

19 October 2023

Kimberly J Nelson

3

author given names

Kimberly J

author last names

Nelson

1 reference

PubMed publication ID

19 October 2023

Alexandra N Wozniak

4

author given names

Alexandra N

author last names

Wozniak

1 reference

PubMed publication ID

19 October 2023

Stacie Beuschel

5

author given names

Stacie

author last names

Beuschel

1 reference

PubMed publication ID

19 October 2023

Bruce Leavitt

6

author given names

Bruce

author last names

Leavitt

1 reference

PubMed publication ID

19 October 2023

Anant Bhave

7

author given names

Anant

author last names

Bhave

1 reference

PubMed publication ID

19 October 2023

Andreas Koenig

9

author given names

Andreas

author last names

Koenig

1 reference

PubMed publication ID

19 October 2023

Edward T Chouchani

10

author given names

Edward T

author last names

Chouchani

1 reference

PubMed publication ID

19 October 2023

Andrew M James

11

author given names

Andrew M

author last names

James

1 reference

PubMed publication ID

19 October 2023

Alexina C Haynes

12

author given names

Alexina C

author last names

Haynes

1 reference

PubMed publication ID

19 October 2023

W Todd Lowther

13

author given names

W Todd

author last names

Lowther

1 reference

PubMed publication ID

19 October 2023

Arti Shukla

15

author given names

Arti

author last names

Shukla

1 reference

PubMed publication ID

19 October 2023

language of work or name

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publication date

2015

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10

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5

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e0127310

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copyright license

Creative Commons Attribution 4.0 International

26 May 2015

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April 2022 Public Data File from Crossref

copyright status

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describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4444329/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

1 reference

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21 March 2017

The Sensitive Balance between the Fully Folded and Locally Unfolded Conformations of a Model Peroxiredoxin

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21 March 2017

Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy

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21 March 2017

The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy

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21 March 2017

Protein Engineering of the Quaternary Sulfiredoxin⋅Peroxiredoxin Enzyme⋅Substrate Complex Reveals the Molecular Basis for Cysteine Sulfinic Acid Phosphorylation

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21 March 2017

FoxM1, a critical regulator of oxidative stress during oncogenesis

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21 March 2017

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21 March 2017

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21 March 2017

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28 September 2017

Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state

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21 March 2017

Structure, mechanism and regulation of peroxiredoxins

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21 March 2017

Regulation of cancer cell metabolism

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21 March 2017

Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria

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21 March 2017

SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria

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21 March 2017

Targeting GRB7/ERK/FOXM1 signaling pathway impairs aggressiveness of ovarian cancer cells

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21 March 2017

Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells

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21 March 2017

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7 April 2017

Physiological roles of mitochondrial reactive oxygen species

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7 April 2017

Mitochondria and cancer

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7 April 2017

Signal transduction by reactive oxygen species

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7 April 2017

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

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7 April 2017

Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells

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28 September 2017

Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine

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28 September 2017

Molecular basis for the resistance of human mitochondrial 2-Cys peroxiredoxin 3 to hyperoxidation

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28 September 2017

A direct and continuous assay for the determination of thioredoxin reductase activity in cell lysates

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28 September 2017

Overexpression of Lon contributes to survival and aggressive phenotype of cancer cells through mitochondrial complex I-mediated generation of reactive oxygen species.

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28 September 2017

Integration of cellular bioenergetics with mitochondrial quality control and autophagy

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28 September 2017

Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells

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28 September 2017

Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro

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28 September 2017

Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes

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28 September 2017

Mitochondrial peroxiredoxin III is a potential target for cancer therapy

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28 September 2017

Micelle-encapsulated thiostrepton as an effective nanomedicine for inhibiting tumor growth and for suppressing FOXM1 in human xenografts

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28 September 2017

The transcription factor FOXM1 is a cellular target of the natural product thiostrepton

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28 September 2017

Differential expression of peroxiredoxins in prostate cancer: consistent upregulation of PRDX3 and PRDX4

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28 September 2017

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28 September 2017

Multiple Functions of Peroxiredoxins: Peroxidases, Sensors and Regulators of the Intracellular Messenger H2O2, and Protein Chaperones

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28 September 2017

Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species

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28 September 2017

A new target for proteasome inhibitors: FoxM1

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28 September 2017

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

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28 September 2017

Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms.

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28 September 2017

FoxM1 is a general target for proteasome inhibitors

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28 September 2017

The cell cycle is a redox cycle: linking phase-specific targets to cell fate

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28 September 2017

Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins.

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28 September 2017

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28 September 2017

Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression

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28 September 2017

The reactive oxygen-driven tumor: relevance to melanoma

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28 September 2017

Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism.

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An extracellular signal-regulated kinase 1- and 2-dependent program of chromatin trafficking of c-Fos and Fra-1 is required for cyclin D1 expression during cell cycle reentry

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28 September 2017

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28 September 2017

Augmented expression of peroxiredoxin I in lung cancer

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28 September 2017

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28 September 2017

Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis

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31 May 2018

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31 May 2018

Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer.

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31 May 2018

AhpF can be dissected into two functional units: tandem repeats of two thioredoxin-like folds in the N-terminus mediate electron transfer from the thioredoxin reductase-like C-terminus to AhpC.

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31 May 2018

Disruption of the mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes

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21 January 2018

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21 January 2018

Redox potential and peroxide reactivity of human peroxiredoxin 3.

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21 January 2018

Interactions of the N-terminal domain of ribosomal protein L11 with thiostrepton and rRNA.

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21 January 2018

Antibiotic susceptibility of mammalian mitochondrial translation

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21 January 2018

Peroxiredoxins in breast carcinoma.

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28 November 2018

Differential expression of manganese superoxide dismutase and catalase in lung cancer

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28 November 2018

A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases

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Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

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Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling

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Overexpression of peroxiredoxins I, II, III, V, and VI in malignant mesothelioma

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https://pubmed.ncbi.nlm.nih.gov/26011724

12 December 2020

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Characterization of the covalent binding of thiostrepton to a thiostrepton-induced protein from Streptomyces lividans

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Identifiers

10.1371/JOURNAL.PONE.0127310

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Consolidated OpenCitations Corpus – April 2017

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2015PLoSO..1027310C

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PMC publication ID

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Consolidated OpenCitations Corpus – April 2017

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