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Mito-priming as a method to engineer Bcl-2 addiction.
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Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
title
Mito-priming as a method to engineer Bcl-2 addiction
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
author
Jonathan Lopez
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1
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Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
Joel S Riley
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3
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Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
Douglas R. Green
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8
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Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
Gabriel Ichim
series ordinal
10
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Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
Stephen Tait
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11
1 reference
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Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
Evangelos Giampazolias
series ordinal
4
object named as
Evangelos Giampazolias
1 reference
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Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
Andrew Oberst
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7
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Andrew Oberst
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Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
author name string
Margaux Bessou
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2
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Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
Franziska Todt
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
Tony Rochegüe
series ordinal
6
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Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
Frank Edlich
series ordinal
9
1 reference
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Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
language of work or name
English
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publication date
2 February 2016
1 reference
stated in
Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
published in
Nature Communications
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stated in
Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
volume
7
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Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
page(s)
10538
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Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
copyright license
Creative Commons Attribution 4.0 International
start time
2 February 2016
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copyright status
copyrighted
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describes a project that uses
ImageJ
1 reference
stated in
Europe PubMed Central
retrieved
11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4740867/fullTextXML
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inferred from PubMed Central ID database lookup
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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
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An inhibitor of Bcl-2 family proteins induces regression of solid tumours
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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
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Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.
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BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response
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A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo
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Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia
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Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B.
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Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
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Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy
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Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.
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Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization
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Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector
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Crossref
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https://api.crossref.org/works/10.1038%2FNCOMMS10538
retrieved
21 January 2018
Identifiers
DOI
10.1038/NCOMMS10538
1 reference
stated in
Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
ADS bibcode
2016NatCo...710538L
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Dimensions Publication ID
1049430299
0 references
PMC publication ID
4740867
1 reference
stated in
Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
PubMed publication ID
26833356
1 reference
stated in
Europe PubMed Central
PMC publication ID
4740867
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26833356%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 March 2020
ResearchGate publication ID
292643152
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