(Q36293251)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25906158%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax (English)

1 reference

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6 March 2020

1

1 reference

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6 March 2020

Martin O'Hely

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25906158%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Mark G Hinds

7

1 reference

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6 March 2020

Erinna Lee

9

1 reference

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6 March 2020

Walter D Fairlie

10

1 reference

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6 March 2020

Ruth Kluck

12

1 reference

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6 March 2020

author name string

K Anwari

2

1 reference

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6 March 2020

R L Ninnis

3

1 reference

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6 March 2020

J Brouwer

4

1 reference

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6 March 2020

M Evangelista

6

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6 March 2020

P E Czabotar

8

1 reference

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6 March 2020

G Dewson

11

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6 March 2020

publication date

23 April 2015

1 reference

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6 March 2020

published in

Cell Death and Disease

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6 March 2020

volume

6

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6 March 2020

page(s)

e1735

1 reference

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Creative Commons Attribution 4.0 International

6 March 2020

copyright license

start time

1 April 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers

30 September 2017

1 reference

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30 September 2017

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Evaluation of the BH3-only protein Puma as a direct Bak activator

30 September 2017

1 reference

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Structural Insights of tBid, the Caspase-8-activated Bid, and Its BH3 Domain

30 September 2017

1 reference

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BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response

30 September 2017

1 reference

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Resilience of death: intrinsic disorder in proteins involved in the programmed cell death

30 September 2017

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BID-induced structural changes in BAK promote apoptosis

30 September 2017

1 reference

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BAK/BAX activation and cytochrome c release assays using isolated mitochondria

30 September 2017

1 reference

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Mechanisms of action of Bcl-2 family proteins

30 September 2017

1 reference

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Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Bak apoptotic function is not directly regulated by phosphorylation

30 September 2017

1 reference

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

30 September 2017

1 reference

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Dynamic interaction of cBid with detergents, liposomes and mitochondria.

30 September 2017

1 reference

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BH3-only proteins in apoptosis at a glance

30 September 2017

1 reference

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BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax

30 September 2017

1 reference

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A unified model of mammalian BCL-2 protein family interactions at the mitochondria.

30 September 2017

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Intrinsic Order and Disorder in the Bcl-2 Member Harakiri: Insights into Its Proapoptotic Activity

30 September 2017

1 reference

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BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

BH3 domains other than Bim and Bid can directly activate Bax/Bak

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Intrinsically disordered proteins in bcl-2 regulated apoptosis.

30 September 2017

1 reference

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Mapping the interaction of pro-apoptotic tBID with pro-survival BCL-XL.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms

30 September 2017

1 reference

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Bcl-XL inhibits membrane permeabilization by competing with Bax.

30 September 2017

1 reference

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

30 September 2017

1 reference

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A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

The BCL-2 protein family: opposing activities that mediate cell death

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

A stapled BID BH3 helix directly binds and activates BAX

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Conformation of membrane-associated proapoptotic tBid

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Solution structure of BID, an intracellular amplifier of apoptotic signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Can the analysis of BH3-only protein knockout mice clarify the issue of 'direct versus indirect' activation of Bax and Bak?

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Membrane promotes tBID interaction with BCL(XL).

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

BIM and tBID are not mechanistically equivalent when assisting BAX to permeabilize bilayer membranes

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

Mitochondrial Release of Pro-apoptotic Proteins

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650538

A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25906158

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25906158

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDDIS.2015.105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25906158%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25906158%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

25906158

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25906158%20AND%20SRC:MED&resulttype=core&format=json