(Q27477757)

2

0 references

Ian Thompson

3

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Srinivas K Chunduru

4

0 references

Steve Herrmann

5

0 references

John O'Connell

6

0 references

Atul Agarwal

7

0 references

Rajiv Chopra

8

0 references

Alfred M Del Vecchio

Antimicrobial Agents and Chemotherapy

9

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language of work or name

English

0 references

publication date

December 2006

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published in

0 references

volume

50

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issue

12

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page(s)

4103-13

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cites work

Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor

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Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

21 March 2017

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In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

21 March 2017

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Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition

21 March 2017

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Requirements for De Novo Initiation of RNA Synthesis by Recombinant Flaviviral RNA-Dependent RNA Polymerases

21 March 2017

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Structure of a T7 RNA polymerase elongation complex at 2.9 A resolution

21 March 2017

1 reference

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Selection of 3'-template bases and initiating nucleotides by hepatitis C virus NS5B RNA-dependent RNA polymerase

21 March 2017

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Oligomerization and Cooperative RNA Synthesis Activity of Hepatitis C Virus RNA-Dependent RNA Polymerase

21 March 2017

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Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

21 March 2017

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Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase

21 March 2017

1 reference

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Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase

21 March 2017

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De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase

21 March 2017

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De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus

21 March 2017

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Nucleotide and amino acid complexity of hepatitis C virus quasispecies in serum and liver

21 March 2017

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21 March 2017

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

21 March 2017

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A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA.

21 March 2017

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Structure of replicating hepatitis C virus (HCV) quasispecies in the liver may not be reflected by analysis of circulating HCV virions

21 March 2017

1 reference

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Efficient initiation of HCV RNA replication in cell culture

21 March 2017

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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

21 March 2017

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Identification of four conserved motifs among the RNA-dependent polymerase encoding elements

21 March 2017

1 reference

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Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Control of hepatitis C: a medicinal chemistry perspective

29 September 2017

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Novel nonnucleoside inhibitor of hepatitis C virus RNA-dependent RNA polymerase

29 September 2017

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Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

29 September 2017

1 reference

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Discontinuous movement and conformational change during pausing and termination by T7 RNA polymerase

29 September 2017

1 reference

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Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

29 September 2017

1 reference

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Promising candidates for the treatment of chronic hepatitis C.

29 September 2017

1 reference

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Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

The essential role of C-terminal residues in regulating the activity of hepatitis C virus RNA-dependent RNA polymerase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Pre-steady-state kinetics of initiation of transcription by T7 RNA polymerase: a new kinetic model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

The specificity loop of T7 RNA polymerase interacts first with the promoter and then with the elongating transcript, suggesting a mechanism for promoter clearance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Studies of promoter recognition and start site selection by T7 RNA polymerase using a comprehensive collection of promoter variants

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Clinical significance of hepatitis C virus genotypes and quasispecies.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Insights into transcription: structure and function of single-subunit DNA-dependent RNA polymerases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

The thumb domain of the P51-subunit is essential for activation of HIV reverse transcriptase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

The distribution of rates of spontaneous mutation over viruses, prokaryotes, and eukaryotes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

A combinatorial ledge: reverse transcriptase fidelity, total body viral burden, and the implications of multiple-drug HIV therapy for the evolution of antiviral resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Marked infidelity of human immunodeficiency virus type 1 reverse transcriptase at RNA and DNA template ends

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

6 Statistical analysis of enzyme kinetic data

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Hepatitis C virus: molecular biology and genetic variability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Canonical 3'-deoxyribonucleotides as a chain terminator for HCV NS5B RNA-dependent RNA polymerase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Oligomeric interaction of hepatitis C virus NS5B is critical for catalytic activity of RNA-dependent RNA polymerase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Hepatitis C virus genotypes and quasispecies

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Selective stimulation of hepatitis C virus and pestivirus NS5B RNA polymerase activity by GTP.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979

Fidelity of HIV-1 reverse transcriptase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693979