(Q27488887)

2

0 references

Seth F Harris

3

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Vincent Leveque

4

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Hannah J Whittington

5

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Sonal Rajyaguru

6

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Gloria Ao-Ieong

7

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Matthew F McCown

8

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April Wong

9

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Anthony M Giannetti

10

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Sophie Le Pogam

11

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Francisco Talamás

12

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Nick Cammack

13

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Isabel Nájera

14

0 references

Klaus Klumpp

Journal of Biological Chemistry

15

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language of work or name

English

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publication date

5 June 2009

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published in

0 references

volume

284

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issue

23

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page(s)

15517-29

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cites work

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The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors

20 March 2017

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Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors

20 March 2017

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Molecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase Inhibitor

20 March 2017

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Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

20 March 2017

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SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells

20 March 2017

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Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro

20 March 2017

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Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor

20 March 2017

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Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation

20 March 2017

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Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

20 March 2017

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Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations

20 March 2017

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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

20 March 2017

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

20 March 2017

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Likelihood-enhanced fast translation functions

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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The CCP4 suite: programs for protein crystallography

20 March 2017

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Non-nucleoside inhibitors of the HCV NS5B polymerase: progress in the discovery and development of novel agents for the treatment of HCV infections.

20 March 2017

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Finger loop inhibitors of the HCV NS5B polymerase: discovery and prospects for new HCV therapy

29 September 2017

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In vitro selected Con1 subgenomic replicons resistant to 2'-C-methyl-cytidine or to R1479 show lack of cross resistance

29 September 2017

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Biochemical and pre-steady-state kinetic characterization of the hepatitis C virus RNA polymerase (NS5BDelta21, HC-J4).

29 September 2017

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The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture

29 September 2017

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Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase

29 September 2017

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HCV antiviral resistance: the impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase

29 September 2017

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Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors.

29 September 2017

1 reference

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Novel nonnucleoside inhibitor of hepatitis C virus RNA-dependent RNA polymerase

29 September 2017

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Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

29 September 2017

1 reference

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Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

29 September 2017

1 reference

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The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently

29 September 2017

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Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

29 September 2017

1 reference

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Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase

29 September 2017

1 reference

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Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site

29 September 2017

1 reference

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Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708848

The culture of designing hepato-biliary randomised trials

19 June 2018

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Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808889200

Mechanistic study of HCV polymerase inhibitors at individual steps of the polymerization reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808889200

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808889200

Initial Binding of the Broad Spectrum Antiviral Nucleoside Ribavirin to the Hepatitis C Virus RNA Polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808889200

Characterization of the metal ion binding properties of the hepatitis C virus RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808889200

Investigating the origin of the slow-binding inhibition of HCV NS3 serine protease by a novel substrate based inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808889200

Functional analysis of RNA binding by the hepatitis C virus RNA-dependent RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808889200