(Q27552840)

English

Paf1p YBR279W

fungal protein found in Saccharomyces cerevisiae S288c

PAF1
YBR279W
Paf1p

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

10 December 2016

RNA polymerase II associated factor Paf1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P38351

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

RNA polymerase II complex binding

determination method

1 reference

21 June 2018

The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

determination method

RNA polymerase II general transcription initiation factor activity

determination method

chromatin binding

determination method

1 reference

21 June 2018

Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

determination method

RNA polymerase II C-terminal domain phosphoserine binding

determination method

1 reference

9 May 2019

Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

protein binding

determination method

7 references

9 May 2019

High-quality binary protein interaction map of the yeast interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

Mpk1 MAPK association with the Paf1 complex blocks Sen1-mediated premature transcription termination.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

Direct Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeast

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

The Paf1 complex has functions independent of actively transcribing RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

Separation of the Saccharomyces cerevisiae Paf1 complex from RNA polymerase II results in changes in its subnuclear localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

Cdc73/Paf1 complex

determination method

4 references

21 June 2018

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

determination method

21 June 2018

Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

determination method

21 June 2018

Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

determination method

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

determination method

Cdc73/Paf1 complex

determination method

5 references

9 May 2019

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

biological process

histone modification

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

global genome nucleotide-excision repair

determination method

1 reference

9 May 2019

Diverse roles of RNA polymerase II-associated factor 1 complex in different subpathways of nucleotide excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

transcription, DNA-templated

determination method

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

determination method

regulation of transcription involved in G1/S transition of mitotic cell cycle

determination method

1 reference

9 May 2019

A role for Ctr9p and Paf1p in the regulation G1 cyclin expression in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

positive regulation of transcription elongation from RNA polymerase I promoter

determination method

1 reference

9 May 2019

The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

regulation of transcription, DNA-templated

determination method

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

positive regulation of transcription elongation from RNA polymerase II promoter

determination method

1 reference

9 May 2019

Molecular evidence indicating that the yeast PAF complex is required for transcription elongation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

rDNA heterochromatin assembly

determination method

1 reference

9 May 2019

The requirements for COMPASS and Paf1 in transcriptional silencing and methylation of histone H3 in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

DNA-templated transcription, termination

determination method

1 reference

9 May 2019

Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

sno(s)RNA 3'-end processing

determination method

1 reference

9 May 2019

A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues

determination method

1 reference

9 May 2019

Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

negative regulation of DNA recombination

determination method

1 reference

9 May 2019

A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

regulation of transcription-coupled nucleotide-excision repair

determination method

1 reference

9 May 2019

Diverse roles of RNA polymerase II-associated factor 1 complex in different subpathways of nucleotide excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

transcription by RNA polymerase I

determination method

2 references

9 May 2019

The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues

determination method

1 reference

9 May 2019

The Paf1 complex has functions independent of actively transcribing RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

regulation of histone H2B ubiquitination

determination method

1 reference

9 May 2019

The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

positive regulation of histone H3-K36 trimethylation

determination method

1 reference

9 May 2019

Regulation of histone modification and cryptic transcription by the Bur1 and Paf1 complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

transcription elongation from RNA polymerase I promoter

determination method

1 reference

9 May 2019

The Paf1 complex is required for efficient transcription elongation by RNA polymerase I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

transcription elongation from RNA polymerase II promoter

determination method

3 references

9 May 2019

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

mRNA 3'-end processing

determination method

1 reference

9 May 2019

The Paf1 complex has functions independent of actively transcribing RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Effectors of lysine 4 methylation of histone H3 in Saccharomyces cerevisiae are negative regulators of PHO5 and GAL1-10.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

regulation of histone H3-K4 methylation

determination method

3 references

9 May 2019

Effectors of lysine 4 methylation of histone H3 in Saccharomyces cerevisiae are negative regulators of PHO5 and GAL1-10.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

9 May 2019

The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

regulation of histone H2B conserved C-terminal lysine ubiquitination

determination method

1 reference

9 May 2019

Direct Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

rRNA processing

determination method

1 reference

9 May 2019

The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Saccharomyces Genome Database ID

1 reference

20 March 2022

Sitelinks

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Multilingual sites(0 entries)

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