(Q27552840)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P38351

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

RNA polymerase II complex binding

1 reference

21 June 2018

The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

RNA polymerase II general transcription initiation factor activity

2 references

10 September 2018

The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II.

Saccharomyces Genome Database ID

SGD

S000000483

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

7 November 2018

The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II.

Saccharomyces Genome Database ID

SGD

S000000483

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

chromatin binding

1 reference

21 June 2018

Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

RNA polymerase II C-terminal domain phosphoserine binding

1 reference

9 May 2019

Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

protein binding

7 references

9 May 2019

High-quality binary protein interaction map of the yeast interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

Mpk1 MAPK association with the Paf1 complex blocks Sen1-mediated premature transcription termination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

Direct Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

cell component

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

1 reference

9 May 2019

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

3 references

9 May 2019

9 May 2019

The Paf1 complex has functions independent of actively transcribing RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

Separation of the Saccharomyces cerevisiae Paf1 complex from RNA polymerase II results in changes in its subnuclear localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

Cdc73/Paf1 complex

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

21 June 2018

Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

21 June 2018

Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

21 June 2018

Cdc73/Paf1 complex

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

IBA

biological process

histone modification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

1 reference

9 May 2019

global genome nucleotide-excision repair

1 reference

9 May 2019

Diverse roles of RNA polymerase II-associated factor 1 complex in different subpathways of nucleotide excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

1 reference

21 June 2018

regulation of transcription involved in G1/S transition of mitotic cell cycle

1 reference

9 May 2019

A role for Ctr9p and Paf1p in the regulation G1 cyclin expression in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

positive regulation of transcription elongation from RNA polymerase I promoter

1 reference

9 May 2019

The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38351&geneProductId=UniProtKB:P38351

1 reference

21 June 2018

regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

positive regulation of transcription elongation from RNA polymerase II promoter

1 reference

9 May 2019

Molecular evidence indicating that the yeast PAF complex is required for transcription elongation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

rDNA heterochromatin assembly

1 reference

9 May 2019

The requirements for COMPASS and Paf1 in transcriptional silencing and methylation of histone H3 in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

DNA-templated transcription, termination

1 reference

9 May 2019

Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

sno(s)RNA 3'-end processing

1 reference

9 May 2019

A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues

1 reference

9 May 2019

Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

negative regulation of DNA recombination

1 reference

9 May 2019

A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

regulation of transcription-coupled nucleotide-excision repair

IGI

1 reference

9 May 2019

Diverse roles of RNA polymerase II-associated factor 1 complex in different subpathways of nucleotide excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

transcription by RNA polymerase I

IGI

The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesis.

2 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues

IGI

1 reference

9 May 2019

The Paf1 complex has functions independent of actively transcribing RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

regulation of histone H2B ubiquitination

1 reference

9 May 2019

The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

positive regulation of histone H3-K36 trimethylation

1 reference

9 May 2019

Regulation of histone modification and cryptic transcription by the Bur1 and Paf1 complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

transcription elongation from RNA polymerase I promoter

1 reference

9 May 2019

The Paf1 complex is required for efficient transcription elongation by RNA polymerase I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

transcription elongation from RNA polymerase II promoter

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

mRNA 3'-end processing

1 reference

9 May 2019

The Paf1 complex has functions independent of actively transcribing RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

negative regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Effectors of lysine 4 methylation of histone H3 in Saccharomyces cerevisiae are negative regulators of PHO5 and GAL1-10.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

regulation of histone H3-K4 methylation

3 references

9 May 2019

Effectors of lysine 4 methylation of histone H3 in Saccharomyces cerevisiae are negative regulators of PHO5 and GAL1-10.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

9 May 2019

The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

regulation of histone H2B conserved C-terminal lysine ubiquitination

1 reference

9 May 2019

Direct Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351

rRNA processing

1 reference

9 May 2019

The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38351