(Q27628961)

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Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases

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scholarly article

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Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases (English)

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author name string

E D Thuresson

1

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M G Malkowski

2

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K M Lakkides

3

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C J Rieke

4

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A M Mulichak

5

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S L Ginell

6

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R M Garavito

7

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W L Smith

8

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language of work or name

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publication date

30 March 2001

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Journal of Biological Chemistry

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276

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13

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10358-65

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Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2

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Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition

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Cyclooxygenases: structural, cellular, and molecular biology

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The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

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Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

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The productive conformation of arachidonic acid bound to prostaglandin synthase

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Comparison of Hydroperoxide Initiator Requirements for the Cyclooxygenase Activities of Prostaglandin H Synthase-1 and −2

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Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid

1 reference

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Cyclooxygenase 2 inhibitors: discovery, selectivity and the future

1 reference

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Spectroscopic evidence for reaction of prostaglandin H synthase-1 tyrosyl radical with arachidonic acid.

1 reference

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Stereospecificity of the hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids produced by cultured bovine endothelial cells

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Prostaglandins in human semen during fish oil ingestion: evidence for in vivo cyclooxygenase inhibition and appearance of novel trienoic compounds.

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Cyclooxygenase-catalyzed formation of 9-hydroxylinoleic acid by guinea pig alveolar macrophages under non-stimulated conditions

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Different catalytically competent arrangements of arachidonic acid within the cyclooxygenase active site of prostaglandin endoperoxide H synthase-1 lead to the formation of different oxygenated products

1 reference

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The membrane binding domains of prostaglandin endoperoxide H synthases 1 and 2. Peptide mapping and mutational analysis

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Prostaglandin G2 levels during reaction of prostaglandin H synthase with arachidonic acid

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NMRPipe: a multidimensional spectral processing system based on UNIX pipes

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

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PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

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Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.

1 reference

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21 January 2018

Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2.

1 reference

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The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

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Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence

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SETOR: hardware-lighted three-dimensional solid model representations of macromolecules

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Hydroperoxide dependence and cooperative cyclooxygenase kinetics in prostaglandin H synthase-1 and -2

1 reference

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The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s)

1 reference

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Rapid kinetics of tyrosyl radical formation and heme redox state changes in prostaglandin H synthase-1 and -2

1 reference

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Coupling of the peroxidase and cyclooxygenase reactions of prostaglandin H synthase

1 reference

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In vivo formation of metabolites of prostaglandins I2 and I3 in the marmoset monkey (Callithrix jacchus) following dietary supplementation with tuna fish oil

1 reference

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21 January 2018

The biosynthesis of the 3-series prostaglandins in rat uterus after alpha-linolenic acid feeding: mass spectroscopy of prostaglandins E and F produced by rat uteri in tissue culture

1 reference

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Peroxidative oxidation of leuco-dichlorofluorescein by prostaglandin H synthase in prostaglandin biosynthesis from polyunsaturated fatty acids

1 reference

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21 January 2018

Oxygenation of 5,8,11-eicosatrienoic acid by prostaglandin endoperoxide synthase and by cytochrome P450 monooxygenase: structure and mechanism of formation of major metabolites

1 reference

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21 January 2018

Naturally occurring conjugated octadecatrienoic acids are strong inhibitors of prostaglandin biosynthesis

1 reference

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Manipulation of platelet aggregation by prostaglandins and their fatty acid precursors: Pharmacological basis for a therapeutic approach

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The role of arginine 120 of human prostaglandin endoperoxide H synthase-2 in the interaction with fatty acid substrates and inhibitors

1 reference

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The formation of stable fatty acid substrate complexes in prostaglandin H(2) synthase-1

1 reference

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Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A

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Identifiers

10.1074/JBC.M009378200

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