(Q33763444)

29 July 2017

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title

Cyclooxygenase 2 inhibitors: discovery, selectivity and the future (English)

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29 July 2017

Marnett LJ

1

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29 July 2017

Kalgutkar AS

series ordinal

2

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29 July 2017

publication date

1 November 1999

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Trends in Pharmacological Sciences

29 July 2017

published in

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29 July 2017

volume

20

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29 July 2017

issue

11

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29 July 2017

page(s)

465-469

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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

29 July 2017

cites work

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7 January 2021

Prostaglandin synthase 2.

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7 January 2021

Cyclooxygenases 1 and 2

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7 January 2021

Differentiation of monocytoid THP-1 cells with phorbol ester induces expression of prostaglandin endoperoxide synthase-1 (COX-1).

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7 January 2021

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

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7 January 2021

Human cyclooxygenase-2 cDNA

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7 January 2021

Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

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7 January 2021

Selective inhibitors of cyclooxygenase-2 (COX-2).

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7 January 2021

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

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7 January 2021

4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2).

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7 January 2021

Aspirin-like molecules that covalently inactivate cyclooxygenase-2.

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7 January 2021

Acetylation of prostaglandin synthase by aspirin

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7 January 2021

Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents.

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7 January 2021

Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs

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7 January 2021

Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase

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7 January 2021

Kinetic basis for selective inhibition of cyclo-oxygenases

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7 January 2021

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis

1 reference

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7 January 2021

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

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7 January 2021

Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2

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7 January 2021

Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2

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7 January 2021

Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition

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7 January 2021

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

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7 January 2021

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

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7 January 2021

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

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7 January 2021

Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site

1 reference

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7 January 2021

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

1 reference

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7 January 2021

Differential utilization of Trk autophosphorylation sites

1 reference

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7 January 2021

Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901385-1

7 January 2021

The dynamics of prostaglandin H synthases. Studies with prostaglandin h synthase 2 Y355F unmask mechanisms of time-dependent inhibition and allosteric activation

1 reference

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7 January 2021

A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901385-1

7 January 2021

Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --> Arg and Ile523 --> val mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901385-1

7 January 2021

Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents

1 reference

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7 January 2021

Structure-based design of COX-2 selectivity into flurbiprofen

1 reference

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7 January 2021

Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects

1 reference

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7 January 2021

Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model

1 reference

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7 January 2021

Selective COX-2 inhibitors: is the water becoming muddy?

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901385-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901385-1

1 reference

7 January 2021

Aspirin use and reduced risk of fatal colon cancer

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7 January 2021

Cyclooxygenase regulates angiogenesis induced by colon cancer cells

1 reference

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7 January 2021

10.1016/S0165-6147(99)01385-1

Identifiers

DOI

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29 July 2017

1 reference