(Q27639619)

English

E. coli dihydroorotate dehydrogenase reveals structural and functional distinctions between different classes of dihydroorotate dehydrogenases

scientific article

In more languages

Statements

scholarly article

0 references

E. coli dihydroorotate dehydrogenase reveals structural and functional distinctions between different classes of dihydroorotate dehydrogenases (English)

0 references

Escherichia coli

0 references

object named as

Sine Larsen

4

0 references

author name string

Sofie Nørager

1

0 references

Kaj Frank Jensen

2

0 references

Olof Björnberg

3

0 references

publication date

September 2002

0 references

0 references

10

0 references

9

0 references

1211-23

0 references

Structure-activity relationships of pyrimidines as dihydroorotate dehydrogenase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Histidine to alanine mutants of human dihydroorotate dehydrogenase. Identification of a brequinar-resistant mutant enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Active site of dihydroorotate dehydrogenase A from Lactococcus lactis investigated by chemical modification and mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of Dihydroorotate Dehydrogenase B

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Purification and characterization of dihydroorotate dehydrogenase A from Lactococcus lactis, crystallization and preliminary X-ray diffraction studies of the enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The activity of Escherichia coli dihydroorotate dehydrogenase is dependent on a conserved loop identified by sequence homology, mutagenesis, and limited proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Sequence analysis and identification of the pyrKDbF operon from Lactococcus lactis including a novel gene, pyrK, involved in pyrimidine biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The B form of dihydroorotate dehydrogenase from Lactococcus lactis consists of two different subunits, encoded by the pyrDb and pyrK genes, and contains FMN, FAD, and [FeS] redox centers.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Dihydro-orotate oxidase of Escherichia coli K12: Purification, properties, and relation to the cytoplasmic membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleotide sequence of the pyrD gene of Escherichia coli and characterization of the flavoprotein dihydroorotate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

8 Dihydroorotate dehdydrogenase (Escherichia coli)

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Anti-peptide immunoglobulins from rabbit and chicken eggs recognise recombinant human dihydroorotate dehydrogenase and a 44-kDa protein from rat liver mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystallization and preliminary X-ray studies of membrane-associated Escherichia coli dihydroorotate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Recombinant human dihydroorotate dehydrogenase: expression, purification, and characterization of a catalytically functional truncated enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of lys100 in human dihydroorotate dehydrogenase: mutagenesis studies and chemical rescue by external amines.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Flavoenzymes: diverse catalysts with recurrent features

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The Escherichia coli K-12 "wild types" W3110 and MG1655 have an rph frameshift mutation that leads to pyrimidine starvation due to low pyrE expression levels

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Selenomethionine substitution of orotidine-5'-monophosphate decarboxylase causes a change in crystal contacts and space group

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Automated MAD and MIR structure solution

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

xdlMAPMAN and xdlDATAMAN - programs for reformatting, analysis and manipulation of biomacromolecular electron-density maps and reflection data sets

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

ALSCRIPT: a tool to format multiple sequence alignments

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900831-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0969-2126(02)00831-6

0 references

PubMed publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q27639619&oldid=1485113335"