(Q27640418)

2

object named as

Joni W Lam

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author name string

Daniel A Erlanson

1

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Christian Wiesmann

3

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Tinh N Luong

4

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Robert L Simmons

5

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Warren L DeLano

6

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Matthew T Burdett

8

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W Michael Flanagan

9

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Dennis Lee

10

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Eric M Gordon

11

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Tom O'Brien

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

12

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publication date

March 2003

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published in

Nature Biotechnology

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volume

21

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issue

3

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page(s)

308-14

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cites work

1 reference

Site-directed ligand discovery

21 April 2017

1 reference

Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality

21 April 2017

1 reference

Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone

21 April 2017

1 reference

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

21 April 2017

1 reference

Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-α

21 April 2017

1 reference

Improved methods for building protein models in electron density maps and the location of errors in these models

21 April 2017

1 reference

The biochemistry of apoptosis

21 April 2017

1 reference

Discovering high-affinity ligands for proteins: SAR by NMR

21 April 2017

1 reference

The finer things in X-ray diffraction data collection

21 April 2017

1 reference

AMoRe: an automated package for molecular replacement

21 April 2017

1 reference

Virtual combinatorial libraries: dynamic generation of molecular and supramolecular diversity by self-assembly

21 April 2017

1 reference

Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: target-accelerated combinatorial synthesis.

21 January 2018

1 reference

Drug discovery by dynamic combinatorial libraries

21 January 2018

1 reference

Dynamic covalent chemistry

21 January 2018

1 reference

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

21 January 2018

1 reference

Programmed cell death: alive and well in the new millennium

21 January 2018

1 reference

Life and death decisions: regulation of apoptosis by proteolysis of signaling molecules

21 January 2018

1 reference

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

21 January 2018

1 reference

Apoptosis: a potential target for discovering novel therapies for cardiovascular diseases

21 January 2018

1 reference

From bench to clinic with apoptosis-based therapeutic agents

21 January 2018

1 reference

Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury

21 January 2018

1 reference

Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases.

21 January 2018

1 reference

Inhibition of human caspases by peptide-based and macromolecular inhibitors

21 January 2018

1 reference

Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

21 January 2018

1 reference

6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity

21 January 2018

1 reference

Quiescent affinity inactivators of protein tyrosine phosphatases

21 January 2018

1 reference

Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design

21 January 2018

1 reference

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

21 January 2018

1 reference

Dynamic combinatorial chemistry

21 January 2018

1 reference

Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks

21 January 2018

1 reference

Selective inactivation of protein tyrosine phosphatase PTP1B by sulfone analogue of naphthoquinone

21 January 2018

1 reference

A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

21 January 2018

1 reference

7 January 2021

P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme

1 reference

7 January 2021

Binding of small molecules to an adaptive protein-protein interface

1 reference

7 January 2021

Mechanism-based inactivation of prostatic acid phosphatase

1 reference

7 January 2021

Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones

1 reference

7 January 2021