(Q27645777)

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X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy

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X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy (English)

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Plasmodium falciparum

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ChEBI release 2020-05-28

Stephanie Valderramos

object named as

Stephanie G Valderramos

11

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David A. Fidock

object named as

David A Fidock

15

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Joel Freundlich

1

object named as

Joel S Freundlich

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author name string

Feng Wang

2

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Han-Chun Tsai

3

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Mack Kuo

4

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Hong-Ming Shieh

5

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John W Anderson

6

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Louis J Nkrumah

7

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Juan-Carlos Valderramos

8

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Min Yu

9

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T R Santha Kumar

10

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William R Jacobs

12

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Guy A Schiehser

13

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David P Jacobus

14

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James C Sacchettini

16

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language of work or name

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publication date

31 August 2007

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Journal of Biological Chemistry

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282

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35

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25436-44

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The global distribution of clinical episodes of Plasmodium falciparum malaria

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Malaria in 2002

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Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum

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Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast

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Fatty Acid synthesis as a target for antimalarial drug discovery.

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Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum

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Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.

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Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase

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Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data

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A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum

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Mass spectrometry-based systems approach for identification of inhibitors of Plasmodium falciparum fatty acid synthase

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Intraerythrocytic Plasmodium falciparum utilize a broad range of serum-derived fatty acids with limited modification for their growth

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Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.

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Novel diphenyl ethers: design, docking studies, synthesis and inhibition of enoyl ACP reductase of Plasmodium falciparum and Escherichia coli.

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Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.

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Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein

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Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain

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Coupling of the de novo fatty acid biosynthesis and lipoylation pathways in mammalian mitochondria

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Triclosan as a substrate and inhibitor of 3'-phosphoadenosine 5'-phosphosulfate-sulfotransferase and UDP-glucuronosyl transferase in human liver fractions

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A plastid of probable green algal origin in Apicomplexan parasites.

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Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

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Refinement of macromolecular structures by the maximum-likelihood method

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The finer things in X-ray diffraction data collection

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Processing of X-ray diffraction data collected in oscillation mode

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The CCP4 suite: programs for protein crystallography

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PHENIX: building new software for automated crystallographic structure determination

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Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

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Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase

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Composition of honeydew excreted by pineapple mealybugs.

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inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

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Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis

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Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis

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Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.

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The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis

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A fast and efficient metal-mediated oxidation of isoniazid and identification of isoniazid-NAD(H) adducts

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Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate

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Kinetic determinants of the interaction of enoyl-ACP reductase from Plasmodium falciparum with its substrates and inhibitors

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Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase

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High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

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Discovery of a rhodanine class of compounds as inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase

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Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type II fatty-acid synthase

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Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP Reductase, a crucial enzyme in fatty acid biosynthesis

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Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR).

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SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

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Slow-tight-binding inhibition of enoyl-acyl carrier protein reductase from Plasmodium falciparum by triclosan

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Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD+.

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Plastid in human parasites

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Synthesis and Evaluation of Substituted Pyrazoles: Potential Antimalarials Targeting the Enoyl‐ACP Reductase of Plasmodium Falciparum

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10.1074/JBC.M701813200

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