(Q31156888)

29 June 2017

title

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (English)

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high-throughput screening

29 June 2017

main subject

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Plasmodium falciparum

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Nicholas A Malmquist

3

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Michael G. Roth

object named as

Michael G Roth

5

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Margaret A. Phillips

7

object named as

Margaret A Phillips

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29 June 2017

6

Pradipsinh K Rathod

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29 June 2017

Jeffrey Baldwin

1

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29 June 2017

Carolyn H Michnoff

2

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29 June 2017

John White

4

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29 June 2017

language of work or name

English

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publication date

28 March 2005

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Journal of Biological Chemistry

29 June 2017

published in

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29 June 2017

volume

280

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29 June 2017

issue

23

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29 June 2017

page(s)

21847-21853

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The global distribution and population at risk of malaria: past, present, and future

29 June 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Clinical status and implications of antimalarial drug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Cytotoxic effects of inhibitors of de novo pyrimidine biosynthesis upon Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Mechanism of action for leflunomide in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Divergent regulation of dihydrofolate reductase between malaria parasite and human host

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Purification and characterization of dihydroorotate dehydrogenase from the rodent malaria parasite Plasmodium berghei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Purification, characterization and localization of mitochondrial dihydroorotate dehydrogenase in Plasmodium falciparum, human malaria parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Analysis of the kinetic mechanism of the bovine liver mitochondrial dihydroorotate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Effect of detergent on "promiscuous" inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

A specific mechanism of nonspecific inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Variations in frequencies of drug resistance in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Antimalarial drug resistance: the pace quickens

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Aromatic quinolinecarboxamides as selective, orally active antibody production inhibitors for prevention of acute xenograft rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Benzophenone photophores in biochemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

Metabolic studies on the new fasciolicidal drug, closantel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501100200

21 January 2018

Identifiers

DOI

10.1074/JBC.M501100200

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29 June 2017

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