(Q27652214)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

0 references

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Rong Cao

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

14

Andrew H-J Wang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

8

Tzu-Ping Ko

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

15

Eric Oldfield

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

author name string

Cammy K-M Chen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Michael P Hudock

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Yonghui Zhang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Joo Hwan No

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Po-Huang Liang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Tao-Hsin Chang

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Shiou-Chi Chang

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Yongcheng Song

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Jordan Axelson

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Anup Kumar

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

language of work or name

English

0 references

publication date

1 September 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

Journal of Medicinal Chemistry

14 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

volume

51

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

issue

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

page(s)

5594-5607

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800762%20AND%20SRC:MED&resulttype=core&format=json

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

14 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Human geranylgeranyl diphosphate synthase. cDNA cloning and expression

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Assessment of phase accuracy by cross validation: the free R value. Methods and applications

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Activity of sulfonium bisphosphonates on tumor cell lines

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Carotenoid biosynthesis: Isolation and characterization of a bifunctional enzyme catalyzing the synthesis of phytoene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Synthesis and biological activity of isoprenoid bisphosphonates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Bisphosphonates and cancer-induced bone disease: beyond their antiresorptive activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Relationship between physicochemical and osteotropic properties of bisphosphonic derivatives: rational design for osteotropic drug delivery system (ODDS).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

A solanesyl-diphosphate synthase localizes in glycosomes of Trypanosoma cruzi.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2552397

Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis

27 November 2018

1 reference

12 December 2020

Crystal Structure of Type-III Geranylgeranyl Pyrophosphate Synthase fromSaccharomyces cerevisiaeand the Mechanism of Product Chain Length Determination

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

1 reference

12 December 2020

A new method for predicting binding affinity in computer-aided drug design

1 reference

12 December 2020

Sample-distance partial least squares: PLS optimized for many variables, with application to CoMFA

1 reference

12 December 2020

https://api.fatcat.wiki/v0/release/ulx32lmvhjeqvlpdbxeery6rya

Identifiers

1 reference

30 July 2022

release_ulx32lmvhjeqvlpdbxeery6rya

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ulx32lmvhjeqvlpdbxeery6rya

30 July 2022

https://api.fatcat.wiki/v0/release/ulx32lmvhjeqvlpdbxeery6rya

1 reference

30 July 2022

https://api.fatcat.wiki/v0/release/ulx32lmvhjeqvlpdbxeery6rya

PubMed publication ID

1 reference

30 July 2022