(Q27654014)

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Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38

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scholarly article

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Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38 (English)

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3

object named as

Derek Duckett

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Philip LoGrasso

10

object named as

Philip LoGrasso

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2

object named as

Jeff Habel

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Theodore M Kamenecka

1

object named as

Ted Kamenecka

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8

object named as

Youseung Shin

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9

object named as

Xinyi Song

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author name string

Weimin Chen

4

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Yuan Yuan Ling

5

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Bozena Frackowiak

6

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Rong Jiang

7

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language of work or name

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publication date

8 May 2009

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Journal of Biological Chemistry

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284

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19

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12853-61

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

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Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors

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N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3

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The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity

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Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity

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Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase

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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

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1 reference

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p38 MAP kinase inhibitors: many are made, but few are chosen.

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Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

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VX-745. Vertex Pharmaceuticals

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Identifiers

10.1074/JBC.M809430200

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