(Q27655637)

2

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Zhiwei Chen

3

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Prafull S Gandhi

4

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Enrico Di Cera

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

24 July 2009

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published in

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volume

284

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issue

30

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page(s)

20034-40

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cites work

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Structure of Human Prostasin, a Target for the Regulation of Hypertension

20 March 2017

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Structural identification of the pathway of long-range communication in an allosteric enzyme

20 March 2017

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Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4

20 March 2017

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Structure of human pro-chymase: a model for the activating transition of granule-associated proteases

20 March 2017

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The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features

20 March 2017

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Crystal structure of a prostate kallikrein isolated from stallion seminal plasma: a homologue of human PSA

20 March 2017

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Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole

20 March 2017

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Activation of endothelial cell protease activated receptor 1 by the protein C pathway

20 March 2017

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Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity

20 March 2017

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Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Bovine chymotrypsinogen A X-ray crystal structure analysis and refinement of a new crystal form at 1.8 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Crystal structure of bovine trypsinogen at 1-8 A resolution. II. Crystallographic refinement, refined crystal structure and comparison with bovine trypsin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Coot: model-building tools for molecular graphics

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

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Stereochemical quality of protein structure coordinates

20 March 2017

1 reference

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Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Single-molecule enzymatic dynamics

20 March 2017

1 reference

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Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Serine protease mechanism and specificity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Thrombin signalling and protease-activated receptors

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Conformational changes in an ultrafast light-driven enzyme determine catalytic activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Activated protein C in sepsis: a critical review

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Interaction between thrombin mutant W215A/E217A and direct thrombin inhibitor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

29 September 2017

1 reference

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Serine peptidases: classification, structure and function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Complement driven by conformational changes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Protease-activated receptors in hemostasis, thrombosis and vascular biology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Redesigning the monovalent cation specificity of an enzyme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

The thrombin epitope recognizing thrombomodulin is a highly cooperative hot spot in exosite I.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Enzyme dynamics during catalysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Site-specific dissection of substrate recognition by thrombin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

An allosteric switch controls the procoagulant and anticoagulant activities of thrombin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Interaction of thrombin des-ETW with antithrombin III, the Kunitz inhibitors, thrombomodulin and protein C. Structural link between the autolysis loop and the Tyr-Pro-Pro-Trp insertion of thrombin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Induction of the bovine trypsinogen-trypsin transition by peptides sequentially similar to the N-terminus of trypsin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Role of the A chain in thrombin function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Conversion of thrombin into an anticoagulant by protein engineering

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740429

Mechanism of charge compensation and impairment of co-operative functions in haemoglobin Tacoma (Arg B12(30)β → ser)

2 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.012344

A role for the two-helix finger of the SecA ATPase in protein translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.012344

Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.012344

Molecular dissection of Na+ binding to thrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.012344

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.012344

21 January 2018

The Protein C Pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.012344

Energetics of thrombin-thrombomodulin interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.012344

Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.012344

Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.012344

Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.012344

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.012344

Rational design of a potent anticoagulant thrombin

21 January 2018

1 reference

12 December 2020

Molecular mapping of thrombin-receptor interactions

1 reference

12 December 2020

The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo

1 reference

12 December 2020

The Anticoagulant Thrombin Mutant W215A/E217A Has a Collapsed Primary Specificity Pocket

1 reference

12 December 2020

High resolution crystal structures of free thrombin in the presence of K(+) reveal the molecular basis of monovalent cation selectivity and an inactive slow form

1 reference

12 December 2020

Crystal structure of thrombin in a self-inhibited conformation

1 reference

12 December 2020

Rapid kinetics of Na+ binding to thrombin

1 reference

12 December 2020

Conformational equilibria in -and -chymotrypsin. The energetics and importance of the salt bridge

1 reference

12 December 2020

Equilibrium and rate constants for the interconversion of two conformations of -chymotrypsin. The existence of a catalytically inactive conformation at neutral p H

1 reference

12 December 2020

The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. The refined crystal structures of the bovine trypsinogen-pancreatic trypsin inhibitor complex and of its ternary complex with Ile-Val at 1.9 A resolution

1 reference

12 December 2020

Release of fibrinopeptides by the slow and fast forms of thrombin

1 reference

12 December 2020

The role of the insertion loop around tryptophan 148 in tthe activity of thrombin

1 reference

12 December 2020

Rational engineering of activity and specificity in a serine protease

1 reference

12 December 2020

Selective loss of fibrinogen clotting in a loop-less thrombin

1 reference

12 December 2020