(Q27656805)

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Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)

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scholarly article

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Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) (English)

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porcine reproductive and respiratory syndrome

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porcine reproductive and respiratory syndrome virus

object named as

Porcine Reproductive and Respiratory Syndrome Virus

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inferred from title

7

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Rolf Hilgenfeld

10

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9

object named as

Jinghua Yan

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2

object named as

Guangwen Lu

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author name string

Xinsheng Tian

1

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Feng Gao

3

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Hao Peng

4

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Youjun Feng

5

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Guangpeng Ma

6

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Kegong Tian

8

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George F Gao

11

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language of work or name

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publication date

2 October 2009

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Journal of Molecular Biology

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392

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4

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977-93

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The CCP4 suite: programs for protein crystallography

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https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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Peptide-plane flipping in proteins

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https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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Complete genome comparison of porcine reproductive and respiratory syndrome virus parental and attenuated strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole

1 reference

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12 December 2020

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Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme: defining the extra domain as a new target for design of highly specific protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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General overview of PRRSV: a perspective from the United States

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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Full-length sequence of a Canadian porcine reproductive and respiratory syndrome virus (PRRSV) isolate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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Variable oligomerization modes in coronavirus non-structural protein 9

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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Expression, purification, and in vitro activity of an arterivirus main proteinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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Conservation of substrate specificities among coronavirus main proteases

1 reference

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12 December 2020

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Refined X-ray crystallographic structure of the poliovirus 3C gene product

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https://pubmed.ncbi.nlm.nih.gov/19646449

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Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

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Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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Genetic variation of the prevailing porcine respiratory and reproductive syndrome viruses occurring on a pig farm upon vaccination.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a protein: identification of two papainlike cysteine proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and Is essential for virus replication.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: evidence that NSP2 acts as a cofactor for the NSP4 serine protease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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The "colorful" epidemiology of PRRS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Biosynthesis, purification, and characterization of the human coronavirus 229E 3C-like proteinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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ESPript: analysis of multiple sequence alignments in PostScript

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Virus-encoded proteinases and proteolytic processing in the Nidovirales.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Serine Proteases: Structure and Mechanism of Catalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Generation of an infectious clone of VR-2332, a highly virulent North American-type isolate of porcine reproductive and respiratory syndrome virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Molecular cloning, expression, purification and crystallographic analysis of PRRSV 3CL protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Prediction of proteinase cleavage sites in polyproteins of coronaviruses and its applications in analyzing SARS-CoV genomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Porcine respiratory and reproductive syndrome virus variants, Vietnam and China, 2007

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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The nsp1alpha and nsp1 papain-like autoproteinases are essential for porcine reproductive and respiratory syndrome virus RNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Maximum-likelihood density modification

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

'Blue ear' disease of pigs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The catalysis of the SARS 3C-like protease is under extensive regulation by its extra domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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Mapping the protein universe

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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Mechanisms and enzymes involved in SARS coronavirus genome expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

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A glutamic acid specific serine protease utilizes a novel histidine triad in substrate binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of crystalline alpha-chymotrypsin. IV. The structure of indoleacryloyl-alpha-chyotrypsin and its relevance to the hydrolytic mechanism of the enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatitis A virus 3C proteinase substrate specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical assessment of important regions in the subunit association and catalytic action of the severe acute respiratory syndrome coronavirus main protease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Porcine reproductive and respiratory syndrome (PRRS or blue-eared pig disease)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subtilisin. Stereochemical mechanism involving transition-state stabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

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Turkey coronavirus non-structure protein NSP15--an endoribonuclease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SARS CoV main proteinase: The monomer-dimer equilibrium dissociation constant

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Automated MAD and MIR structure solution

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

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The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/19646449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JMB.2009.07.062

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